Evidence map›Paper›PMID 26617513›Full record

ReviewFrontiers in aging neuroscience2015

Mechanical Stimulation (Pulsed Electromagnetic Fields "PEMF" and Extracorporeal Shock Wave Therapy "ESWT") and Tendon Regeneration: A Possible Alternative.

Federica Rosso, Davide E Bonasia, Antonio Marmotti, Umberto Cottino, Roberto Rossi

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07495254 (Effectiveness of Combined Super Inductive System), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07495254 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effectiveness of Combined Super Inductive System (SIS) Therapy With Therapeutic Physical Therapy Exercise and Health Education in Lateral Elbow Tendinopathy

TypeinterventionalSponsorUniversity of Vic - Central University of CataloniaRan2026 to 2028Enrolled224ConditionsLateral Epicondylitis (Tennis Elbow), Lateral Epicondylalgia, Lateral Elbow TendinopathyArmsSuper Inductive System (SIS), therapeutic dose, Super Inductive System (SIS), non-therapeutic dose (active placebo), Therapeutic Exercise Program, Health Education
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  4. Short-term effects of extracorporeal shock wave therapy on bone mineral density in postmenopausal osteoporotic patients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
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  13. The Role of PEMFs on Bone Healing: An In Vitro Study.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Federica RossoDepartment of Orthopaedics and Traumatology, AO Mauriziano Umberto I Torino, Italy.
Davide E BonasiaDepartment of Orthopaedics and Traumatology, AO Mauriziano Umberto I Torino, Italy.
Antonio MarmottiDepartment of Orthopaedics and Traumatology, AO Mauriziano Umberto I Torino, Italy.
Umberto CottinoDepartment of Orthopaedics and Traumatology, AO Mauriziano Umberto I Torino, Italy.
Roberto RossiDepartment of Orthopaedics and Traumatology, AO Mauriziano Umberto I Torino, Italy.
A. O. Ordine Mauriziano di Torino · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis of tendon degeneration and tendinopathy is still partially unclear. However, an active role of metalloproteinases (MMP), growth factors, such as vascular endothelial growth factor (VEGF) and a crucial role of inflammatory elements and cytokines was demonstrated. Mechanical stimulation may play a role in regulation of inflammation. In vitro studies demonstrated that both pulsed electromagnetic fields (PEMF) and extracorporeal shock wave therapy (ESWT) increased the expression of pro-inflammatory cytokine such as interleukin (IL-6 and IL-10). Moreover, ESWT increases the expression of growth factors, such as transforming growth factor β(TGF-β), (VEGF), and insulin-like growth factor 1 (IGF1), as well as the synthesis of collagen I fibers. These pre-clinical results, in association with several clinical studies, suggest a potential effectiveness of ESWT for tendinopathy treatment. Recently PEMF gained popularity as adjuvant for fracture healing and bone regeneration. Similarly to ESWT, the mechanical stimulation obtained using PEMFs may play a role for treatment of tendinopathy and for tendon regeneration, increasing in vitro TGF-β production, as well as scleraxis and collagen I gene expression. In this manuscript the rational of mechanical stimulations and the clinical studies on the efficacy of extracorporeal shock wave (ESW) and PEMF will be discussed. However, no clear evidence of a clinical value of ESW and PEMF has been found in literature with regards to the treatment of tendinopathy in human, so further clinical trials are needed to confirm the promising hypotheses concerning the effectiveness of ESWT and PEMF mechanical stimulation.

Indexed as

extracorporeal shockwaves therapymechanical stimulationpulsed electromagnetic fieldstendinopathytendontendon regeneration

Identifiers

PMID26617513
PMCPMC4637423
OpenAlexW2165744104

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.