ArticleJournal of the American Statistical Association
IsoDOT Detects Differential RNA-isoform Expression/Usage with respect to a Categorical or Continuous Covariate with High Sensitivity and Specificity.
Article in Journal of the American Statistical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Article
- MGLM: An R Package for Multivariate Categorical Data Analysis.The R journal · 2018Article
- Comparative genomic evidence for the involvement of schizophrenia risk genes in antipsychotic effects.Molecular psychiatry · 2018Article
- A randomized approach to speed up the analysis of large-scale read-count data in the application of CNV detection.BMC bioinformatics · 2018Article
- Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
- Regression Models For Multivariate Count Data.Journal of computational and graphical statistics : a joint publication of American Statistical Association, Institute of Mathematical Statistics, Interface Foundation of North America · 2017Article
- A STATISTICAL MODEL TO ASSESS (ALLELE-SPECIFIC) ASSOCIATIONS BETWEEN GENE EXPRESSION AND EPIGENETIC FEATURES USING SEQUENCING DATA.The annals of applied statistics · 2016Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
We have developed a statistical method named IsoDOT to assess differential isoform expression (DIE) and differential isoform usage (DIU) using RNA-seq data. Here isoform usage refers to relative isoform expression given the total expression of the corresponding gene. IsoDOT performs two tasks that cannot be accomplished by existing methods: to test DIE/DIU with respect to a continuous covariate, and to test DIE/DIU for one case versus one control. The latter task is not an uncommon situation in practice, e.g., comparing the paternal and maternal alleles of one individual or comparing tumor and normal samples of one cancer patient. Simulation studies demonstrate the high sensitivity and specificity of IsoDOT. We apply IsoDOT to study the effects of haloperidol treatment on the mouse transcriptome and identify a group of genes whose isoform usages respond to haloperidol treatment.
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Registered trials
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