Evidence map›Paper›PMID 26617327›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2016

Gender and Time to Arrival among Ischemic Stroke Patients in the Greater Cincinnati/Northern Kentucky Stroke Study.

Tracy E Madsen, Heidi Sucharew, Brian Katz, Kathleen A Alwell, Charles J Moomaw, Brett M Kissela, Matthew L Flaherty, Daniel Woo, Pooja Khatri, Simona Ferioli and 4 more

Abstract readMulticenter Study
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  14. Stroke Center Certification Is Associated With Improved Guideline Concordance.American journal of medical quality : the official journal of the American College of Medical Quality
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tracy E MadsenDivision of Sex and Gender in Emergency Medicine, Department of Emergency Medicine, The Alpert Medical School of Brown University, Providence, Rhode Island. Electronic address: tracy_madsen@brown.edu.
Heidi SucharewDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Brian KatzNeuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Kathleen A AlwellDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Charles J MoomawDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Brett M KisselaNeuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Matthew L FlahertyNeuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Daniel WooNeuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Pooja KhatriNeuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Simona FerioliNeuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Jason MackeyDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana.
Sharyl MartiniDepartment of Neurology, Baylor College of Medicine, Houston, Texas.
Felipe De Los Rios La RosaNeuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology, Sanna Healthcare Network, Lima, Peru.
Dawn KleindorferNeuroscience Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
STROKE INCIDENCE AND OUTCOME AMONG BLACKS AND WHITESR01NS030678 · NINDS · UNIVERSITY OF CINCINNATI · PI KISSELA, BRETT M, KLEINDORFER, DAWN O · 1993 to 2024
$26.7M
Cerebrovascular Fellowship Training ProgramT32NS047996 · NINDS · UNIVERSITY OF CINCINNATI · PI Joseph Paul Broderick, Stacie Demel · 2006 to 2026
$3.7M
NCATS NIH HHS UL1 TR001425NINDS NIH HHS R01 NS030678NINDS NIH HHS R01 NS 30678NINDS NIH HHS T32 NS047996
6 · The paper itself

Abstract

backgroundSome studies of stroke patients report longer prehospital delays in women, but others conflict; studies vary in their inclusion of factors including age and stroke severity. We aimed to investigate the relationship between gender and time to emergency department (ED) arrival and the influence of age and stroke severity on this relationship.

methodsIschemic stroke patients 20 years old or older who presented to 15 hospitals within a 5-county region of Greater Cincinnati/Northern Kentucky during 2010 were included. Time from symptom onset to ED arrival and covariates were abstracted by study nurses and reviewed by study physicians. Data were analyzed using logistic regression with time to arrival dichotomized at 3 hours or less in the overall sample and then stratified by National Institutes of Health Stroke Scale (NIHSS) and age.

results1991 strokes (55% women) were included. Time to arrival was slightly longer in women (geometric mean 337 minutes [95% confidence interval {CI} 307-369] versus 297 [95% CI 268-329], P = .05), and 24% of women versus 27% of men arrived within 3 hours (P = .15). After adjusting for age, race, NIHSS, living situation, and other covariates, gender was not associated with delayed time to arrival (OR = 1.00, 95% CI .78-1.28). This did not change across age or NIHSS categories.

conclusionsAfter adjusting for factors including age, NIHSS score, and living alone, women and men with ischemic stroke had similar times to arrival. Arrival time is not likely a major contributor to differences in outcome between men and women.

Indexed as

Sex FactorsAdultAgedAge of OnsetBrain IschemiaEmergency Medical ServicesFemaleHumansKentuckyMaleMiddle AgedMultivariate AnalysisOdds RatioOhioRetrospective StudiesStrokeacute strokedelayGenderischemicstroke

Identifiers

PMID26617327
PMCPMC4779702

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.