Evidence map›Paper›PMID 26617254›Full record

Trial reportInternational journal of obesity (2005)2016

Physical activity intensity and type 2 diabetes risk in overweight youth: a randomized trial.

J Hay, K Wittmeier, A MacIntosh, B Wicklow, T Duhamel, E Sellers, H Dean, E Ready, L Berard, D Kriellaars and 3 more

Abstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in International journal of obesity (2005), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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  17. [Physical activity intervention for non-alcoholic fatty liver disease in children].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2020
    Article
  18. Review
  19. Physical activity in adolescents and children and relationship to metabolic health.Current opinion in endocrinology, diabetes, and obesity · 2019
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

J HayChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
K WittmeierChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
A MacIntoshChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
B WicklowChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
T DuhamelFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada.
E SellersChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
H DeanChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
E ReadyFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada.
L BerardDiabetes Research Group, Health Sciences Centre of Winnipeg, Winnipeg, Manitoba, Canada.
D KriellaarsFaculty of Medical Rehabilitation, University of Manitoba, Winnipeg, Manitoba, Canada.
G X ShenDiabetes Research Group, Health Sciences Centre of Winnipeg, Winnipeg, Manitoba, Canada.
P GardinerFaculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada.
J McGavockChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.

Funding

Canadian Institutes of Health Research
6 · The paper itself

Abstract

backgroundThe chronic effects of high-intensity endurance training on metabolic health outcomes in overweight adolescents remains poorly understood.

objectiveTo test the hypothesis that high-intensity endurance training (ET) is superior to moderate-intensity ET for improving risk factors for type 2 diabetes in overweight adolescents. DESIGN AND

methodsIn this randomized trial, 106 overweight and obese adolescents (15.2 years; 76% female; 62% Caucasian) were randomly assigned to high-intensity ET (70-85% of heart rate reserve, n=38), moderate-intensity ET (40-55% heart rate reserve; n=32) or control for 6 months (n=36). The primary and secondary outcome measures were insulin sensitivity assessed using a frequently sampled intravenous glucose tolerance test and hepatic triglyceride content with magnetic resonance spectroscopy. Exploratory outcomes were cardiorespiratory fitness, physical activity and MRI and dual x-ray absorptiometry-derived measures of adiposity.

resultsThe study had 96% retention and attendance was 61±21% and 55±24% in the high- and moderate-intensity ET arms. Intention-to-treat analyses revealed that, at follow-up, insulin sensitivity was not different between high-intensity (-1.0 mU kg(-1) min(-1); 95% confidence interval (CI): -1.6, +1.4 mU kg(-1) min(-1)) and moderate-intensity (+0.26 mU kg(-1) min(-1); 95% CI: -1.3, +1.8 mU kg(-1) min(-1)) ET arms compared with controls (interaction, P=0.97). Similarly, hepatic triglyceride at follow-up was not different in high-intensity (-1.7% fat/water (F/W); 95% CI: -7.0, +3.6% F/W) and moderate-intensity (-0.40% FW; 95% CI: -6.0, +5.3% F/W) ET compared with controls. Both high intensity (+4.4 ml per kg-FFM (fat-free mass) per minute; 95% CI: 1.7, 7.1 ml kg-FFM(-1) min(-1)) and moderate intensity (+4.4 ml kg-FFM(-1) min(-1); 95% CI: 1.6, 7.3 ml kg-FFM(-1) min(-1)) increased cardiorespiratory fitness, relative to controls (interaction P<0.001).

conclusionsET improves cardiorespiratory fitness among obese adolescents; however, owing to lack of compliance, the influence of exercise intensity on insulin sensitivity and hepatic triglycerides remains unclear.

Indexed as

Exercise TherapyPhysical EnduranceAdolescentBody Mass IndexCanadaCardiovascular Physiological PhenomenaDiabetes Mellitus, Type 2FemaleHumansInsulin ResistanceMalePatient CompliancePediatric ObesityPhysical FitnessResistance TrainingRisk FactorsTriglycerides

Identifiers

PMID26617254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.