Evidence map›Paper›PMID 26616837›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2016

Exploring possible association between DβH genotype (C1021T), early onset of conduct disorder and psychopathic traits in juvenile delinquents.

Johan Isaksson, Elena L Grigorenko, Lars Oreland, Britt Af Klinteberg, Roman A Koposov, Vladislav Ruchkin

Abstract read
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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Johan IsakssonDepartment of Neuroscience, Uppsala University, Uppsala, Sweden. johan.isaksson@neuro.uu.se.
Elena L GrigorenkoChild Study Center, Yale University, New Haven, CT, USA.
Lars OrelandDepartment of Neuroscience, Uppsala University, Uppsala, Sweden.
Britt Af KlintebergStockholm University, Stockholm, Sweden.
Roman A KoposovUniversity of Tromsø, Tromsø, Norway.
Vladislav RuchkinDepartment of Neuroscience, Uppsala University, Uppsala, Sweden.
Uppsala University · SELomonosov Moscow State University · RUStockholm University · SEUiT The Arctic University of Norway · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early onset of conduct disorder (CD) with callous-unemotional traits has been linked to low levels of dopamine β-hydroxylase (DβH), an enzyme involved in dopamine turnover. The C1021T polymorphism in the DβH gene is a major quantitative-trait locus, regulating the level of DβH. In this study of juvenile delinquents from Northern Russia (n = 180), the polymorphism at -1021 was associated neither with early-onset CD nor with psychopathic traits. Association was found between psychopathic traits and early-onset CD, ADHD and mania.

Indexed as

AdolescentAnalysis of VarianceAntisocial Personality DisorderConduct DisorderDopamine beta-HydroxylaseGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHumansJuvenile DelinquencyMalePhenotypePolymorphism, Single NucleotideRussiaDopamine beta-HydroxylaseConduct disorderDβHGeneticPsychopathy

Identifiers

PMID26616837
OpenAlexW2271651693

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.