Evidence map›Paper›PMID 26616727›Full record

ArticleActa pharmacologica Sinica2016

Adiponectin downregulation is associated with volume overload-induced myocyte dysfunction in rats.

Li-li Wang, Dori Miller, Desiree Wanders, Gayani Nanayakkara, Rajesh Amin, Robert Judd, Edward E Morrison, Ju-ming Zhong

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Li-li WangDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Alabama, USA.
Dori MillerDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Alabama, USA.
Desiree WandersDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Alabama, USA.
Gayani NanayakkaraDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Alabama, USA.
Rajesh AminDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Auburn University, Alabama, USA.
Robert JuddDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Alabama, USA.
Edward E MorrisonDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Alabama, USA.
Ju-ming ZhongDepartment of Anatomy, Physiology and Pharmacology, College of Veterinary Medicine, Auburn University, Alabama, USA.
Auburn University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimAdiponectin has been reported to exert protective effects during pathological ventricular remodeling, but the role of adiponectin in volume overload-induced heart failure remains unclear. In this study we investigated the effect of adiponectin on cardiac myocyte contractile dysfunction following volume overload in rats.

methodsVolume overload was surgically induced in rats by infrarenal aorta-vena cava fistula. The rats were intravenously administered adenoviral adiponectin at 2-, 6- and 9-weeks following fistula. The protein expression of adiponectin, adiponectin receptors (AdipoR1/R2 and T-cadherin) and AMPK activity were measured using Western blot analyses. Isolated ventricular myocytes were prepared at 12 weeks post-fistula to examine the contractile performance of myocytes and intracellular Ca(2+) transient.

resultsA-V fistula resulted in significant reductions in serum and myocardial adiponectin levels, myocardial adiponectin receptor (AdipoR1/R2 and T-cadherin) levels, as well as myocardial AMPK activity. Consistent with these changes, the isolated myocytes exhibited significant depression in cell shortening and intracellular Ca(2+) transient. Administration of adenoviral adiponectin significantly increased serum adiponectin levels and prevented myocyte contractile dysfunction in fistula rats. Furthermore, pretreatment of isolated myocytes with recombinant adiponectin (2.5 μg/mL) significantly improved their contractile performance in fistula rats, but had no effects in control or adenoviral adiponectin-administered rats.

conclusionThese results demonstrate a positive correlation between adiponectin downregulation and volume overload-induced ventricular remodeling. Adiponectin plays a protective role in volume overload-induced heart failure.

Indexed as

Down-RegulationAdiponectinAMP-Activated Protein KinasesAnimalsCalciumCells, CulturedHeart FailureMaleMyocytes, CardiacRatsRats, Sprague-DawleyAdiponectinAdipoq protein, ratAMP-Activated Protein KinasesCalcium

Identifiers

PMID26616727
PMCPMC4753373
OpenAlexW2397483557

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.