ArticleEarly intervention in psychiatry2017
McLean OnTrack: a transdiagnostic program for early intervention in first-episode psychosis.
Article in Early intervention in psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The proportion of people with a first episode of psychosis admitted to hospital at initial presentation: a systematic review and meta-analysis.Psychological medicine · 2025Pooled it
- Transition of Substance-Induced, Brief, and Atypical Psychoses to Schizophrenia: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2020Pooled it
- Widespread cortical thinning and subcortical alterations in mood and psychotic disorders across first-episode and chronic stages.Journal of affective disorders · 2026Article
- Macro- and Microstructural Alterations in the Midbrain in Early Psychosis Associates with Clinical Symptom Scores.eNeuro · 2025Article
- Substance Use in Early Psychosis: Mixed Methods Impact on Family.Journal of dual diagnosis · 2025Article
- Pilot development and feasibility of telehealth Community Reinforcement and Family Training (CRAFT) for early psychosis and substance use.Psychiatry research · 2022Article
- WellSpace: Peer-led groups for first-episode psychosis before and during the COVID era.Early intervention in psychiatry · 2022Article
- The support, treatment, and resilience (STAR) program for youth at clinical high-risk of psychosis.Schizophrenia research · 2022Article
- Research Domain Criteria (RDoC): Progress and Potential.Current directions in psychological science · 2022Article
- Impact of Substance Use Disorder on Between-Network Brain Connectivity in Early Psychosis.Schizophrenia bulletin open · 2022Article
- Effects of COVID-19 pandemic on mental health outcomes in a cohort of early psychosis patients.Early intervention in psychiatry · 2021Article
- Implementing Coordinated Specialty Care for First Episode Psychosis: A Review of Barriers and Solutions.Community mental health journal · 2021Review
- Heterogeneity of Outcomes and Network Connectivity in Early-Stage Psychosis: A Longitudinal Study.Schizophrenia bulletin · 2021Article
- Diagnostic Stability of Primary Psychotic Disorders in a Research Sample.Frontiers in psychiatry · 2021Article
- Evolving Concepts of the Schizophrenia Spectrum: A Research Domain Criteria Perspective.Frontiers in psychiatry · 2021Article
- Abnormal Brain Bioenergetics in First-Episode Psychosis.Schizophrenia bulletin open · 2021Article
- Two-year diagnostic stability in a real-world sample of individuals with early psychosis.Early intervention in psychiatry · 2020Article
- Return to College After a First Episode of Psychosis.Schizophrenia bulletin open · 2020Article
- Transdiagnostic psychiatry: a systematic review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2019Article
- Decreased peak alpha frequency and impaired visual evoked potentials in first episode psychosis.NeuroImage. Clinical · 2019Article
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Authors and funding
11 authors.
Funding
Abstract
aimsMost programs specializing in the treatment of first-episode psychosis in the United States focus on schizophrenia. However, many early psychosis patients do not fit into this diagnostic category. Here we describe McLean OnTrack, an intensive outpatient treatment program that accepts all comers with first-episode psychosis.
methodsWe assessed baseline characteristics of patients in the 2.5 years since program initiation. We examined how initial referral diagnoses compare with current diagnoses, calculating the proportion of diagnostic changes.
resultsAt 2.5 years, patients in McLean OnTrack consist of 30 (33.0%) individuals with primary psychotic disorder, 40 (44.0%) with affective psychosis, 19 (20.9%) with psychotic disorder not otherwise specified (NOS) who do not meet full criteria for either category and two (2.2%) individuals with no psychosis. Although patients with affective psychosis had higher pre-morbid functioning, all three categories of psychosis had similar rates of prior hospitalizations and substance use. The retention rate in the psychotic disorder NOS group was lower than that in affective and primary psychotic disorders. Finally, diagnoses changed over the course of treatment in 50.5% of patients.
conclusionsDiagnostic heterogeneity appears to be the norm among patients with first-episode psychosis, and diagnoses commonly evolve over the illness course. Baseline indices of illness severity were similar across categories and suggest the need for early intervention, irrespective of specific diagnosis. We discuss the benefits and challenges of a transdiagnostic approach to early intervention in first-episode psychosis, treating patients who share many but not all characteristics.
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