Evidence map›Paper›PMID 26616161›Full record

ArticleScientific reports2015

Zeolite Nanoparticles for Selective Sorption of Plasma Proteins.

M Rahimi, E-P Ng, K Bakhtiari, M Vinciguerra, H Ali Ahmad, H Awala, S Mintova, M Daghighi, F Bakhshandeh Rostami, M de Vries and 4 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 11 institutions in 6 countries.

M RahimiFaculty of Science, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
E-P NgSchool of Chemical Sciences, University Sains Malaysia, 11800 USM, Malaysia.
K BakhtiariDepartment of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands.
M VinciguerraInstitute for Liver and Digestive Health, Division of Medicine, University College London (UCL), London, United Kingdom.
H Ali AhmadLaboratory of Catalysis and Spectroscopy, ENSICAEN, University of Caen, CNRS, 6 Boulevard du Maréchal Juin, 14050 Caen, France.
H AwalaLaboratory of Catalysis and Spectroscopy, ENSICAEN, University of Caen, CNRS, 6 Boulevard du Maréchal Juin, 14050 Caen, France.
S MintovaLaboratory of Catalysis and Spectroscopy, ENSICAEN, University of Caen, CNRS, 6 Boulevard du Maréchal Juin, 14050 Caen, France.
M DaghighiUniversity of Groningen, University Medical Center Groningen, Department Bioengineering, Groningen, the Netherlands.
F Bakhshandeh RostamiDepartment of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Iran.
M de VriesUniversity of Groningen, University Medical Center Groningen, Department Cell Biology, Department medical proteomics, Groningen, the Netherlands.
M M MotazackerDepartment of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
M P PeppelenboschDepartment of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands.
M MahmoudiDivision of Cardiovascular Medicine, School of Medicine, Stanford University, Stanford, California, USA.
F RezaeeUniversity of Groningen, University Medical Center Groningen, Department Cell Biology, Department medical proteomics, Groningen, the Netherlands.
École Nationale Supérieure d'Ingénieurs de Caen · FRErasmus MC · NLUniversity Medical Center Groningen · NLAcademic Medical Center · NLCentre National de la Recherche Scientifique · FRInstitute for Advanced Studies in Basic Sciences · IRSanquin · NLStanford University · USUniversiti Sains Malaysia · MYUniversity College London · GBUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The affinity of zeolite nanoparticles (diameter of 8-12 nm) possessing high surface area and high pore volume towards human plasma proteins has been investigated. The protein composition (corona) of zeolite nanoparticles has been shown to be more dependent on the plasma protein concentrations and the type of zeolites than zeolite nanoparticles concentration. The number of proteins present in the corona of zeolite nanoparticles at 100% plasma (in vivo state) is less than with 10% plasma exposure. This could be due to a competition between the proteins to occupy the corona of the zeolite nanoparticles. Moreover, a high selective adsorption for apolipoprotein C-III (APOC-III) and fibrinogen on the zeolite nanoparticles at high plasma concentration (100%) was observed. While the zeolite nanoparticles exposed to low plasma concentration (10%) exhibited a high selective adsorption for immunoglobulin gamma (i.e. IGHG1, IGHG2 and IGHG4) proteins. The zeolite nanoparticles can potentially be used for selectively capture of APOC-III in order to reduce the activation of lipoprotein lipase inhibition during hypertriglyceridemia treatment. The zeolite nanoparticles can be adapted to hemophilic patients (hemophilia A (F-VIII deficient) and hemophilia B (F-IX deficient)) with a risk of bleeding, and thus might be potentially used in combination with the existing therapy.

Indexed as

Blood ProteinsNanoparticlesZeolitesAdsorptionApolipoprotein C-IIIBlood CoagulationChromatography, LiquidFibrinogenHumansNitrogenProtein CoronaTandem Mass SpectrometryApolipoprotein C-IIIBlood ProteinsFibrinogenNitrogenProtein CoronaZeolites

Identifiers

PMID26616161
PMCPMC4663482
OpenAlexW2215115346

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.