ArticleBiomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals2015
A Japanese cross-sectional multicentre study of biomarkers associated with cardiovascular disease in smokers and non-smokers.
Article in Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02103751 (A Multi-center Study to Determine the Levels of Biomarkers of Potential Harm and Biomarkers of Exposure to Cigarette Smoke in Asian Adult Smokers and Non-smokers), which is not on this map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-center Study to Determine the Levels of Biomarkers of Potential Harm and Biomarkers of Exposure to Cigarette Smoke in Asian Adult Smokers and Non-smokers
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Heat-not-burn tobacco products: a systematic literature review.Tobacco control · 2019Pooled it
- Influence of cigarette smoking on cardio-inflammatory biomarkers among healthy individuals or cardiopulmonary disorder patients: systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
- Comparison of profiles of biomarkers of potential harm among healthy adults who used heated tobacco products, smoked combustible cigarettes, or who had never smoked: a cross-sectional, observational study.Internal and emergency medicine · 2026Observational
- Prevalence of Cardiovascular Risk Factors in Smokers Versus Non-smokers: A Cross-Sectional Analysis.Cureus · 2025Article
- Evaluation of common carotid artery wall stiffness by shear wave elastography in smokers and non-smokers.Tobacco induced diseases · 2024Article
- Biomarkers of Inflammation and Oxidative Stress among Adult Former Smoker, Current E-Cigarette Users-Results from Wave 1 PATH Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Electronic and Tobacco Cigarettes Alter Polyunsaturated Fatty Acids and Oxidative Biomarkers.Circulation research · 2021Article
- Differences in Levels of Biomarkers of Potential Harm Among Users of a Heat-Not-Burn Tobacco Product, Cigarette Smokers, and Never-Smokers in Japan: A Post-Marketing Observational Study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021Observational
- Effects of cigarette smoking on blood lipids in Korean men: Cardiovascular and Metabolic Diseases Etiology Research Center cohort.The Korean journal of internal medicine · 2020Article
- Influence of smoking on levels of urinary 8-iso Prostaglandin F2α.Toxicology reports · 2019Article
- Effects of Switching to the Menthol Tobacco Heating System 2.2, Smoking Abstinence, or Continued Cigarette Smoking on Clinically Relevant Risk Markers: A Randomized, Controlled, Open-Label, Multicenter Study in Sequential Confinement and Ambulatory Settings (Part 2).Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2018Article
- Influence of smoking and smoking cessation on levels of urinary 11-dehydro thromboxane BToxicology reports · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We performed a cross-sectional, multicentre study in Japan to detect the differences in biomarkers of exposure and cardiovascular biomarkers between smokers and non-smokers. Several clinically relevant cardiovascular biomarkers differed significantly between smokers and non-smokers, including lipid metabolism (high-density lipoprotein cholesterol concentrations - lower in smokers), inflammation (fibrinogen and white blood cell count - both higher in smokers), oxidative stress (8-epi-prostaglandin F2α - higher in smokers) and platelet activation (11-dehydro-thromboxane B2 - higher in smokers) (p ≤ 0.0001). These results provide further evidence showing that cardiovascular biomarkers can discriminate smokers from non-smokers, and could be used to evaluate the risks associated with tobacco products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.