ReviewJournal of the American College of Cardiology2016
Medical Therapy With Versus Without Revascularization in Stable Patients With Moderate and Severe Ischemia: The Case for Community Equipoise.
Review in Journal of the American College of Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA)
International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Chronic Kidney Disease Trial
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Update of the Brazilian Guideline on Nuclear Cardiology - 2020.Arquivos brasileiros de cardiologia · 2020Guideline
- TransEndocardial Injection of Autologous Expanded CD34Stem cell reviews and reports · 2026Trial
- Initial Invasive or Conservative Strategy for Stable Coronary Disease.The New England journal of medicine · 2020 · on this mapTrial
- Invasive and medical management approaches to non-acute myocardial ischaemic syndromes.Nature reviews. Cardiology · 2026Review
- Impact on cardiovascular outcome of coronary revascularization-induced changes in ischemic perfusion defect and myocardial flow reserve.European journal of nuclear medicine and molecular imaging · 2024Article
- Non-invasive fractional flow reserve estimation using deep learning on intermediate left anterior descending coronary artery lesion angiography images.Scientific reports · 2024Article
- Rates of Elective Percutaneous Coronary Intervention in England and Wales: Impact of COURAGE and ORBITA Trials.Journal of the American Heart Association · 2022Article
- Multi-Modality Imaging for Prevention of Coronary Artery Disease and Myocardial Infarction in the General Population: Ready for Prime Time?Journal of clinical medicine · 2022Review
- Regional variation in coronary angiography rates: the association with supply factors and the role of indication: a spatial analysis.BMC cardiovascular disorders · 2022Article
- Screening for participants in the ISCHEMIA trial: Implications for clinical research.Journal of clinical and translational science · 2022Article
- SPECT myocardial perfusion imaging-based ischemia-guided early coronary revascularization improves survival: More fuel to the fire.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Patients with Non-Obstructive Coronary Artery Disease Require Strict Control of All Cardiovascular Risk Factors: Results from the Polish Local Population Medical Records.Journal of clinical medicine · 2021Article
- Coronary Revascularization and Long-Term Survivorship in Chronic Coronary Syndrome.Journal of clinical medicine · 2021Review
- Identification of Flow-Limiting Coronary Stenosis With PCS: A New Cost-Effective Index Derived From the Product of Corrected TIMI Frame Count and Percent Diameter Stenosis.Frontiers in cardiovascular medicine · 2021Article
- Epidemiology and pathophysiologic insights of coronary atherosclerosis relevant for contemporary non-invasive imaging.Cardiovascular diagnosis and therapy · 2020Review
- The risk for subsequent coronary interventions in a local Polish population.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2020Article
- Randomized Trials Versus Common Sense and Clinical Observation: JACC Review Topic of the Week.Journal of the American College of Cardiology · 2020Review
- Improving the Design of Future PCI Trials for Stable Coronary Artery Disease: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2020Review
- Revascularization versus drug therapy for coronary artery disease in patients aged over 80 years: a real-world study.Cardiovascular diagnosis and therapy · 2020Article
- Risk factors differ by first manifestation of cardiovascular disease in type 1 diabetes.Diabetes research and clinical practice · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
All patients with stable ischemic heart disease (SIHD) should be managed with guideline-directed medical therapy (GDMT), which reduces progression of atherosclerosis and prevents coronary thrombosis. Revascularization is also indicated in patients with SIHD and progressive or refractory symptoms, despite medical management. Whether a strategy of routine revascularization (with percutaneous coronary intervention or coronary artery bypass graft surgery as appropriate) plus GDMT reduces rates of death or myocardial infarction, or improves quality of life compared to an initial approach of GDMT alone in patients with substantial ischemia is uncertain. Opinions run strongly on both sides, and evidence may be used to support either approach. Careful review of the data demonstrates the limitations of our current knowledge, resulting in a state of community equipoise. The ongoing ISCHEMIA trial (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) is being performed to determine the optimal approach to managing patients with SIHD, moderate-to-severe ischemia, and symptoms that can be controlled medically. (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches [ISCHEMIA]; NCT01471522).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.