Evidence map›Paper›PMID 26615906›Full record

ArticleJournal of diabetes and its complications2016

The association between antidepressant use and glycemic control in the Southern Community Cohort Study (SCCS).

Jamie R Kammer, Akiko S Hosler, Emily Leckman-Westin, Greg DiRienzo, Chandra Y Osborn

Abstract read
In one paragraph

Article in Journal of diabetes and its complications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Jamie R KammerUniversity at Albany School of Public Health, Rensselaer, NY, United States. Electronic address: JRKammer@gmail.com.
Akiko S HoslerUniversity at Albany School of Public Health, Rensselaer, NY, United States.
Emily Leckman-WestinUniversity at Albany School of Public Health, Rensselaer, NY, United States.
Greg DiRienzoUniversity at Albany School of Public Health, Rensselaer, NY, United States.
Chandra Y OsbornVanderbilt University Medical Center, Nashville, TN, United States.

Funding

Southern Community Cohort StudyR01CA092447 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BLOT, WILLIAM J., ZHENG, WEI · 2001 to 2015
$74.0M
Vanderbilt Center for Diabetes Translation ResearchP30DK092986 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ELASY, TOM A · 2011 to 2020
$6.7M
Developmental Infrastructure CoreR24HD044943 · NICHD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI BUSHWAY, SHAWN D · 2004 to 2016
$4.8M
Improving Medication Adherence among Underserved Patients with Type 2 DiabetesR01DK100694 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MAYBERRY, LINDSAY S. · 2014 to 2018
$3.3M
Leveraging Patient Portals to Improve Medication Adherence in Type 2 DiabetesK01DK087894 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OSBORN, CHANDRA Y. · 2011 to 2015
$710k
NCI NIH HHS R01 CA092447NICHD NIH HHS R24 HD044943NIDDK NIH HHS K01 DK087894NIDDK NIH HHS K01DK087894NIDDK NIH HHS P30 DK092986NIDDK NIH HHS R01 DK100694NIDDK NIH HHS R01DK100694-01A1
6 · The paper itself

Abstract

introductionAmong people with diabetes, comorbid depression has been associated with suboptimal health outcomes. However, the independent impact of antidepressant use on glycemic control (A1C) has not been well understood. RESEARCH DESIGN AND

methodsThe Southern Community Cohort Study collected self-reported antidepressant use and measured continuous A1C in a sample of racially diverse adults with and without diabetes who visited community health clinics serving low-income families in the southeastern United States (N=2445). Crude and adjusted linear regression models were used to examine the relationships between using specific antidepressant subclasses and continuous A1C.

resultsAlthough use of any single antidepressant subclass was not a significant predictor of A1C level, there was a significant association between using multiple antidepressant subclasses and higher A1C, specifically among individuals with diabetes (standardized effect size=.12, p=.04).

conclusionAmong adults with diabetes, the use of multiple antidepressant subclasses may be a risk factor for suboptimal glycemic control. Prospective studies are needed to confirm the direction of this observation, as the present study was limited by a cross-sectional design and small sample size.

Indexed as

AdultAgedAntidepressive AgentsBlood GlucoseCohort StudiesCross-Sectional StudiesDepressionDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedUnited StatesAntidepressive AgentsBlood GlucoseA1CAntidepressantsDiabetesDrug interactionGlycemic control

Identifiers

PMID26615906
PMCPMC4787537

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.