ArticleBurns : journal of the International Society for Burn Injuries2016
Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics.
Article in Burns : journal of the International Society for Burn Injuries, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Mitochondria as a Therapeutic Target for Burn Injury.Biomolecules · 2026Review
- HOUSING TEMPERATURE ALTERS BURN-INDUCED HYPERMETABOLISM IN MICE.Shock (Augusta, Ga.) · 2025Article
- Burns results in profound muscle protein wasting in Sprague Dawley rats that is not resolved using the lipolysis inhibitor, acipimox.PloS one · 2025Article
- Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns.Frontiers in immunology · 2023Article
- Modern Aspects of Burn Injury Immunopathogenesis and Prognostic Immunobiochemical Markers (Mini-Review).Biotech (Basel (Switzerland)) · 2022Review
- Small animal models of thermal injury.Methods in cell biology · 2022Review
- Independent of physical activity, volumetric muscle loss injury in a murine model impairs whole-body metabolism.PloS one · 2021Article
- Brown adipose tissue recruitment in a rodent model of severe burns.Burns : journal of the International Society for Burn Injuries · 2020Article
- Stimulating Factors and Origins of Precursor Cells in Traumatic Heterotopic Ossification Around the Temporomandibular Joint in Mice.Frontiers in cell and developmental biology · 2020Article
- Burn Trauma Acutely Increases the Respiratory Capacity and Function of Liver Mitochondria.Shock (Augusta, Ga.) · 2018Article
- The Role of Mitochondrial Stress in Muscle Wasting Following Severe Burn Trauma.Journal of burn care & research : official publication of the American Burn Association · 2018Review
- Inducible satellite cell depletion attenuates skeletal muscle regrowth following a scald-burn injury.The Journal of physiology · 2017Article
- Hepatic mitochondrial bioenergetics in aged C57BL/6 mice exhibit delayed recovery from severe burn injury.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Inhibition of NFE2L2-Antioxidant Response Element Pathway by Mitochondrial Reactive Oxygen Species Contributes to Development of Cardiomyopathy and Left Ventricular Dysfunction in Chagas Disease.Antioxidants & redox signaling · 2017Article
- Burn Serum Stimulates Myoblast Cell Death Associated with IL-6-Induced Mitochondrial Fragmentation.Shock (Augusta, Ga.) · 2017Article
- ER stress and subsequent activated calpain play a pivotal role in skeletal muscle wasting after severe burn injury.PloS one · 2017Article
- Hypermetabolism and hypercatabolism of skeletal muscle accompany mitochondrial stress following severe burn trauma.American journal of physiology. Endocrinology and metabolism · 2016Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Altered skeletal muscle mitochondrial function contributes to the pathophysiological stress response to burns. However, the acute and chronic impact of burn trauma on skeletal muscle bioenergetics remains poorly understood. Here, we determined the temporal relationship between burn trauma and mitochondrial function in murine skeletal muscle local to and distal from burn wounds. Male BALB/c mice (8-10 weeks old) were burned by submersion of the dorsum in water (∼ 95 °C) to create a full thickness burn on ∼ 30% of the body. Skeletal muscle was harvested spinotrapezius underneath burn wounds (local) and the quadriceps (distal) of sham and burn treated mice at 3h, 24h, 4d and 10d post-injury. Mitochondrial respiration was determined in permeabilized myofiber bundles by high-resolution respirometry. Caspase 9 and caspase 3 protein concentration were determined by western blot. In muscle local to burn wounds, respiration coupled to ATP production was significantly diminished at 3h and 24h post-injury (P<0.001), as was mitochondrial coupling control (P<0.001). There was a 5- (P<0.05) and 8-fold (P<0.001) increase in respiration in response to cytochrome at 3h and 24h post burn, respectively, indicating damage to the outer mitochondrial membranes. Moreover, we also observed greater active caspase 9 and caspase 3 in muscle local to burn wounds, indicating the induction of apoptosis. Distal muscle mitochondrial function was unaltered by burn trauma until 10d post burn, where both respiratory capacity (P<0.05) and coupling control (P<0.05) were significantly lower than sham. These data highlight a differential response in muscle mitochondrial function to burn trauma, where the timing, degree and mode of dysfunction are dependent on whether the muscle is local or distal to the burn wound.
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