ArticleBrain structure & function2016
A central mesencephalic reticular formation projection to the Edinger-Westphal nuclei.
Article in Brain structure & function, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
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- Precerebellar paramedian tract cell groups connections: I. Oculomotor internuclear projections.Brain structure & function · 2025Article
- Time-on-task effects on human pupillary and saccadic metrics after theta burst transcranial magnetic stimulation over the frontal eye field.IBRO neuroscience reports · 2023Article
- Pupil Size Is Sensitive to Low-Level Stimulus Features, Independent of Arousal-Related Modulation.eNeuro · 2023Article
- Brainstem sources of input to the central mesencephalic reticular formation in the macaque.Experimental brain research · 2023Article
- Emerging order of anomalous eye movements with progressive drowsiness.Journal of vision · 2023Article
- Is the central mesencephalic reticular formation a purely horizontal gaze center?Brain structure & function · 2022Article
- Eye tracking identifies biomarkers in α-synucleinopathies versus progressive supranuclear palsy.Journal of neurology · 2022Article
- Fatigue and Arousal Modulations Revealed by Saccade and Pupil Dynamics.International journal of environmental research and public health · 2022Article
- Ocular Autonomic Nervous System: An Update from Anatomy to Physiological Functions.Vision (Basel, Switzerland) · 2022Review
- A Novel Tectal/Pretectal Population of Premotor Lens Accommodation Neurons.Investigative ophthalmology & visual science · 2022Article
- Eye Movements in Mild Traumatic Brain Injury: Ocular Biomarkers.Journal of eye movement research · 2022Article
- The cost of correcting for error during sensorimotor adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neural control of rapid binocular eye movements: Saccade-vergence burst neurons.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Background luminance effects on pupil size associated with emotion and saccade preparation.Scientific reports · 2020Article
- Is Primate Lens Accommodation Unilaterally or Bilaterally Controlled?Investigative ophthalmology & visual science · 2020Article
- Pupil Size as a Window on Neural Substrates of Cognition.Trends in cognitive sciences · 2020Review
- Pupillary light reflex circuits in the macaque monkey: the preganglionic Edinger-Westphal nucleus.Brain structure & function · 2020Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The central mesencephalic reticular formation, a region associated with horizontal gaze control, has recently been shown to project to the supraoculomotor area in primates. The Edinger-Westphal nucleus is found within the supraoculomotor area. It has two functionally and anatomically distinct divisions: (1) the preganglionic division, which contains motoneurons that control both the actions of the ciliary muscle, which focuses the lens, and the sphincter pupillae muscle, which constricts the iris, and (2) the centrally projecting division, which contains peptidergic neurons that play a role in food and fluid intake, and in stress responses. In this study, we used neuroanatomical tracers in conjunction with immunohistochemistry in Macaca fascicularis monkeys to examine whether either of these Edinger-Westphal divisions receives synaptic input from the central mesencephalic reticular formation. Anterogradely labeled reticular axons were observed making numerous boutonal associations with the cholinergic, preganglionic motoneurons of the Edinger-Westphal nucleus. These associations were confirmed to be synaptic contacts through the use of confocal and electron microscopic analysis. The latter indicated that these terminals generally contained pleomorphic vesicles and displayed symmetric, synaptic densities. Examination of urocortin-1-positive cells in the same cases revealed fewer examples of unambiguous synaptic relationships, suggesting the centrally projecting Edinger-Westphal nucleus is not the primary target of the projection from the central mesencephalic reticular formation. We conclude from these data that the central mesencephalic reticular formation must play a here-to-for unexpected role in control of the near triad (vergence, lens accommodation and pupillary constriction), which is used to examine objects in near space.
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