Evidence map›Paper›PMID 26615555›Full record

ArticleEuropean radiology2016

Multiparametric fully-integrated 18-FDG PET/MRI of advanced gastric cancer for prediction of chemotherapy response: a preliminary study.

Dong Ho Lee, Se Hyung Kim, Seock-Ah Im, Do-Youn Oh, Tae-Yong Kim, Joon Koo Han

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Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Review
  6. Current status and future perspectives on neoadjuvant therapy in gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021
    Article
  7. Article
  8. Review
  9. The role of MRI in the diagnosis and treatment of gastric cancer.Diagnostic and interventional radiology (Ankara, Turkey) · 2020
    Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Cardiovascular diagnosis and therapy · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Radiomic signature ofTheranostics · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dong Ho LeeDepartment of Radiology, Seoul National University Hospital, 28, Yeongon-dong, Jongno-gu, Seoul, 110-744, Korea.
Se Hyung KimDepartment of Radiology, Seoul National University Hospital, 28, Yeongon-dong, Jongno-gu, Seoul, 110-744, Korea. shkim7071@gmail.com.
Seock-Ah ImDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Do-Youn OhDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Tae-Yong KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Joon Koo HanDepartment of Radiology, Seoul National University Hospital, 28, Yeongon-dong, Jongno-gu, Seoul, 110-744, Korea.
Seoul National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate usefulness of multiparametric fully integrated 18-FDG PET/MRI in predicting treatment response after chemotherapy for unresectable advanced gastric cancers (AGCs).

methodsEleven patients with unresectable AGCs underwent multiparametric 18-FDG PET/MRI examinations prior to chemotherapy. Perfusion parameters obtained via dynamic contrast-enhanced MRI, apparent diffusion coefficient values from diffusion-weighted images, and maximum standardized uptake values (SUVmax) from 18-FDG PET were measured. For parameters obtained from 18-FDG PET/MRI data, interobserver agreement was obtained using intraclass correlation coefficients (ICC) and chemotherapy response relationship was evaluated using the Mann-Whitney test and receiver operating characteristic analysis.

resultsAfter chemotherapy, six patients were classified into the responder group and five patients into the non-responder group. For all parameters, moderate to nearly perfect agreement was achieved (ICC = 0.452-0.911). K (trans) values (P = 0.018) and initial area under the curves (iAUCs) (P = 0.045) of gastric cancers were significantly higher in responder group than in non-responder group. The area under the curve was 0.917 for K (trans) and 0.867 for iAUC. However, SUVmax values were not significantly different between the two groups.

conclusionMultiparametric approach using fully integrated 18-FDG PET/MRI was shown to be feasible for patients with unresectable gastric cancers. In addition, K (trans) and iAUC values can be used as early predictive markers for chemotherapy response. KEY POINTS: • Multiparametric 18-FDG PET/MRI is feasible for patients with unresectable advanced gastric cancer • K (trans) and iAUC were significantly higher in the responder group of patients • K (trans) , iAUC can be utilized as early predictive markers for chemotherapeutic response.

Indexed as

Neoplasm StagingAdultAgedAntineoplastic AgentsFemaleFluorodeoxyglucose F18HumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsROC CurveStomach NeoplasmsAntineoplastic AgentsFluorodeoxyglucose F18RadiopharmaceuticalsAdvanced gastric cancerDynamic contrast-enhanced MRIMultiparametric 18F-fluorodexoyglucose PET/MRIPalliative chemotherapyResponse prediction

Identifiers

PMID26615555
OpenAlexW2176150385

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.