ArticleMycopathologia2016
In Vitro Activities of Five Antifungal Drugs Against Opportunistic Agents of Aspergillus Nigri Complex.
Article in Mycopathologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Coinfection of Pulmonary Hydatid Cyst and Aspergilloma: Case Report and Systematic Review.Mycopathologia · 2016Pooled it
- Epidemiological Characteristics of ClinicalJournal of fungi (Basel, Switzerland) · 2026Article
- Antifungal susceptibility ofFrontiers in public health · 2026Article
- The frequency distribution of Aspergillus section Nigri from clinical and environmental samples in Iran.BMC microbiology · 2025Article
- Review
- cyp51A mutations, protein modeling, and efflux pump gene expression reveals multifactorial complexity towards understanding Aspergillus section Nigri azole resistance mechanism.Scientific reports · 2024Article
- Resistance of Black Aspergilli Species from Grape Vineyards to SDHI, QoI, DMI, and Phenylpyrrole Fungicides.Journal of fungi (Basel, Switzerland) · 2023Article
- Otomycosis in the South of Iran with a High Prevalence of Tympanic Membrane Perforation: A Hospital-Based Study.Mycopathologia · 2022Review
- Molecular Identification and Antifungal Susceptibility of Yeasts and Molds Isolated from Patients with Otomycosis.Mycopathologia · 2021Article
- Emergence of Triazole Resistance inCurrent fungal infection reports · 2021Review
- Antifungal susceptibility profiles of otomycosis etiological agents in Ahvaz, Iran.Current medical mycology · 2020Article
- Otomycosis Due to the Rare Fungi Talaromyces purpurogenus, Naganishia albida and Filobasidium magnum.Mycopathologia · 2020Article
- Antifungal Activity of a Novel Triazole, Efinaconazole and Nine Comparators against 354 Molecularly Identified Aspergillus Isolates.Mycopathologia · 2020Article
- Treatment of Otomycosis in Ears with Tympanic Membrane Perforation is Easier with Paper Patch.Turkish archives of otorhinolaryngology · 2019Article
- The potency of luliconazole against clinical and environmentalIranian journal of microbiology · 2019Article
- New Insights into the Cyp51 Contribution to Azole Resistance inAntimicrobial agents and chemotherapy · 2019Article
- LowAntimicrobial agents and chemotherapy · 2018Article
- Species Identification andAntimicrobial agents and chemotherapy · 2018Article
- Otomycosis in Damascus, Syria: Etiology and clinical features.Current medical mycology · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Black aspergilli, particularly Aspergillus niger and A. tubingensis, are the most common etiological agents of otomycosis followed by onychomycosis, pulmonary aspergillosis and aspergilloma. However, so far there is no systematic study on their antifungal susceptibility profiles. A collection of 124 clinical and environmental species of black aspergilli consisted of A. niger, A. tubingensis, A. uvarum. A. acidus and A. sydowii were verified by DNA sequencing of the partial β-tubulin gene. MICs of amphotericin B, itraconazole, voriconazole, posaconazole, and MECs of caspofungin were performed based on CLSI M38-A2. Posaconazole and caspofungin had the lowest MIC range (0.016-0.125 µg/ml and 0.008-0.031 µg/ml, respectively), followed by amphotericin B (0.25-4 µg/ml), voriconazole (0.125-16 µg/ml) and itraconazole (0.25 to >16) in an increasing order. Some strains of A. niger showed high MIC value for itraconazole and voriconazole (>16 µg/ml), in contrast only environmental isolates of A. tubingensis had high itraconazole MICs (>16 µg/ml). These results confirm that posaconazole and caspofungin are potential drugs for treatment of aspergillosis due to opportunistic agents of Aspergillus Nigri complex. However, in vivo efficacy remains to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.