Evidence map›Paper›PMID 26615406›Full record

ArticleObesity surgery2016

Pharmacotherapy in Conjunction with a Diet and Exercise Program for the Treatment of Weight Recidivism or Weight Loss Plateau Post-bariatric Surgery: a Retrospective Review.

Jennifer Schwartz, Umer I Chaudhry, Andrew Suzo, Nicholas Durkin, Allison M Wehr, Kathy S Foreman, Kristen Tychonievich, Dean J Mikami, Bradley J Needleman, Sabrena F Noria

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 5 pooled it
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 5 syntheses or guidelines pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Clinical outcomes associated with anti-obesity medications in real-world practice: A systematic literature review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
    Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Review
  9. Review
  10. The Efficacy and Safety of Liraglutide in Patients Remaining Obese 6 Months after Metabolic Surgery.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024
    Article
  11. Weight Loss Pharmacotherapy: Current and Future Therapies.Gastrointestinal endoscopy clinics of North America · 2024
    Review
  12. Review
  13. Article
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  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jennifer SchwartzThe Comprehensive Weight Management and Bariatric Surgery Program, Center for Minimally Invasive Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Room 558, Columbus, OH, 43210, USA.
Umer I Chaudhry
Andrew SuzoThe Comprehensive Weight Management and Bariatric Surgery Program, Center for Minimally Invasive Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Room 558, Columbus, OH, 43210, USA.
Nicholas Durkin
Allison M WehrThe Comprehensive Weight Management and Bariatric Surgery Program, Center for Minimally Invasive Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Room 558, Columbus, OH, 43210, USA.
Kathy S ForemanThe Comprehensive Weight Management and Bariatric Surgery Program, Center for Minimally Invasive Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Room 558, Columbus, OH, 43210, USA.
Kristen Tychonievich
Dean J MikamiThe Comprehensive Weight Management and Bariatric Surgery Program, Center for Minimally Invasive Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Room 558, Columbus, OH, 43210, USA.
Bradley J NeedlemanThe Comprehensive Weight Management and Bariatric Surgery Program, Center for Minimally Invasive Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Room 558, Columbus, OH, 43210, USA.
Sabrena F NoriaThe Comprehensive Weight Management and Bariatric Surgery Program, Center for Minimally Invasive Surgery, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, Room 558, Columbus, OH, 43210, USA. Sabrena.noria@osumc.edu.
The Ohio State University Wexner Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBariatric surgery is an effective therapeutic option for management of obesity. However, weight recidivism (WR) and weight loss plateau (WLP) are common problems. We present our experience with the use of two pharmacotherapies in conjunction with our standard diet and exercise program in those patients who experienced WR or WLP.

methodsFrom June 2010 to April 2014, bariatric surgery patients who experienced WR or WLP after undergoing Roux-en-Y gastric bypass (RYGB) or laparoscopic adjustable gastric banding (LAGB), and who were treated with phentermine (Ph) or phentermine-topiramate (PhT), were reviewed retrospectively. Generalized estimating equations were used to compare patient weights through 90 days between initial surgery type and medication type. Patient weights, medication side effect, and co-morbidities were collected during the first 90 days of therapy.

resultsFifty-two patients received Ph while 13 patients received PhT. Overall, patients in both groups lost weight. Among those whose weights were recorded at 90 days, patients on Ph lost 6.35 kg (12.8% excess weight loss (EWL); 95% confidence interval (CI) 4.25, 8.44) and those prescribed PhT lost 3.81 kg (12.9% EWL; CI 1.08, 6.54). Adjusting for baseline weight, time since surgery, and visit through 90 days, patients treated with Ph weighed significantly less than those on PhT throughout the course of this study (1.35 kg lighter; 95% CI 0.17, 2.53; p = 0.025). There were no serious side effects reported.

conclusionsPhentermine and phentermine-topirimate in addition to diet and exercise appear to be viable options for weight loss in post-RYGB and LAGB patients who experience WR or WLP.

Indexed as

AdultAnti-Obesity AgentsBariatric SurgeryDiet, ReducingExercise TherapyFemaleFructoseHumansLaparoscopyMaleMiddle AgedObesityPhentermineRetrospective StudiesTopiramateWeight LossAnti-Obesity AgentsFructosePhentermineTopiramateBariatric surgeryPhenterminePhentermine–topiramateWeight loss plateauWeight recidivism

Identifiers

PMID26615406
OpenAlexW2175876676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.