ArticleGenome biology and evolution2015
Reticulate Speciation and Barriers to Introgression in the Anopheles gambiae Species Complex.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 42 citations in OpenAlex.
- Comparative Genomics of the Testacea Group of Drosophila Reveals Introgression and Variation in Chromosome Size and Structure.Genome biology and evolution · 2025Article
- Population genomic evidence of a putative 'far-west' African cryptic taxon in the Anopheles gambiae complex.Communications biology · 2024Article
- Mitochondrial Variation in Anopheles gambiae and Anopheles coluzzii: Phylogeographic Legacy and Mitonuclear Associations With Metabolic Resistance to Pathogens and Insecticides.Genome biology and evolution · 2024Article
- Homing gene drives can transfer rapidly between Anopheles gambiae strains with minimal carryover of flanking sequences.Nature communications · 2024Article
- Speciation within theResearch square · 2024Article
- A targeted amplicon sequencing panel to simultaneously identify mosquito species and Plasmodium presence across the entire Anopheles genus.Molecular ecology resources · 2022Article
- Selection and isolation define a heterogeneous divergence landscape between hybridizing Heliconius butterflies.Evolution; international journal of organic evolution · 2021Article
- Advances and opportunities in malaria population genomics.Nature reviews. Genetics · 2021Review
- A population genomic unveiling of a new cryptic mosquito taxon within the malaria-transmitting Anopheles gambiae complex.Molecular ecology · 2021Article
- Article
- Unveiling mosquito cryptic species and their reproductive isolation.Insect molecular biology · 2020Review
- Evaluating the probability of CRISPR-based gene drive contaminating another species.Evolutionary applications · 2020Article
- Fine-scale species delimitation: speciation in process and periodic patterns in nudibranch diversity.ZooKeys · 2020Article
- Coalescent Analysis of Phylogenomic Data Confidently Resolves the Species Relationships in the Anopheles gambiae Species Complex.Molecular biology and evolution · 2018Article
- Variation in recombination frequency and distribution across eukaryotes: patterns and processes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Review
- Prediction and Prevention of Parasitic Diseases Using a Landscape Genomics Framework.Trends in parasitology · 2017Review
- Chromosomal Speciation in the Genomics Era: Disentangling Phylogenetic Evolution of Rock-wallabies.Frontiers in genetics · 2017Article
- Insect phylogenomics.Insect molecular biology · 2015Review
- Genomic analysis of MHC-based mate choice in the monogamous California mouse.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Speciation as a process remains a central focus of evolutionary biology, but our understanding of the genomic architecture and prevalence of speciation in the face of gene flow remains incomplete. The Anopheles gambiae species complex of malaria mosquitoes is a radiation of ecologically diverse taxa. This complex is well-suited for testing for evidence of a speciation continuum and genomic barriers to introgression because its members exhibit partially overlapping geographic distributions as well as varying levels of divergence and reproductive isolation. We sequenced 20 genomes from wild A. gambiae s.s., Anopheles coluzzii, Anopheles arabiensis, and compared these with 12 genomes from the "GOUNDRY" subgroup of A. gambiae s.l. Amidst a backdrop of strong reproductive isolation, we find strong evidence for a speciation continuum with introgression of autosomal chromosomal regions among species and subgroups. The X chromosome, however, is strongly differentiated among all taxa, pointing to a disproportionately large effect of X chromosome genes in driving speciation among anophelines. Strikingly, we find that autosomal introgression has occurred from contemporary hybridization between A. gambiae and A. arabiensis despite strong divergence (∼5× higher than autosomal divergence) and isolation on the X chromosome. In addition to the X, we find strong evidence that lowly recombining autosomal regions, especially pericentromeric regions, serve as barriers to introgression secondarily to the X. We show that speciation with gene flow results in genomic mosaicism of divergence and introgression. Such a reticulate gene pool connecting vector taxa across the speciation continuum has important implications for malaria control efforts.
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