Evidence map›Paper›PMID 26615021›Full record

ArticleThe Gerontologist2016

Longitudinal Cognitive Trajectories of Women Veterans from the Women's Health Initiative Memory Study.

Claudia B Padula, Julie C Weitlauf, Allyson C Rosen, Gayle Reiber, Barbara B Cochrane, Michelle J Naughton, Wenjun Li, Michelle Rissling, Kristine Yaffe, Julie R Hunt and 3 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in The Gerontologist, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  8. Article
  9. Evidence Review-Social Determinants of Health for Veterans.Journal of general internal medicine · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Claudia B PadulaVA Palo Alto Health Care System, Sierra Pacific MIRECC and Department of Psychiatry & Behavioral Sciences, Stanford University, Palo Alto, California. padula@stanford.edu.
Julie C WeitlaufVA Palo Alto Health Care System, Sierra Pacific MIRECC and Department of Psychiatry & Behavioral Sciences, Stanford University, Palo Alto, California. VA Palo Alto Health Care System, Center for Innovation to Implementation, Palo Alto, California.
Allyson C RosenVA Palo Alto Health Care System, Sierra Pacific MIRECC and Department of Psychiatry & Behavioral Sciences, Stanford University, Palo Alto, California.
Gayle ReiberHealth Services Research and Development, VA Puget Sound Health Care System, Seattle, Washington.
Barbara B CochraneSchool of Nursing, University of Washington School of Nursing, Seattle.
Michelle J NaughtonDivision of Population Sciences, College of Medicine, The Ohio State University, Columbus.
Wenjun LiDepartment of Medicine, University of Massachusetts Medical School, Worcester. Department of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester.
Michelle RisslingDurham VA Medical Center, Mid-Atlantic MIRECC, Durham, North Carolina.
Kristine YaffeUCSF Department of Psychiatry, Neurology and Epidemiology and Biostatistics, San Francisco VA Medical Center, Sierra Pacific MIRECC, California.
Julie R HuntFred Hutchinson Cancer Research Center, Seattle, Washington.
Marcia L StefanickDepartment of Medicine (Stanford Center for Prevention Research), Stanford University School of Medicine, California. Department of Obstetrics & Gynecology, Stanford University School of Medicine, California.
Mary K GoldsteinVA Palo Alto Health Care System, GRECC, Stanford University School of Medicine, Department of Medicine, Center for Primary Care & Outcomes Research, Palo Alto, California.
Mark A EspelandWake Forest School of Medicine, Department of Biostatistical Sciences, One Medical Center Blvd, Winston-Salem, North Carolina.
VA Palo Alto Health Care System · USFred Hutch Cancer Center · USMental Illness Research, Education and Clinical Centers · USUniversity of Massachusetts Chan Medical School · USVA Puget Sound Health Care System · US

Funding

NHLBI NIH HHS HHSN268201100001INHLBI NIH HHS HHSN268201100002INHLBI NIH HHS HHSN268201100003INHLBI NIH HHS HHSN268201100004INHLBI NIH HHS HHSN268201100046CNIA NIH HHS HHSN271201100004CWHI NIH HHS HHSN268201100001CWHI NIH HHS HHSN268201100002CWHI NIH HHS HHSN268201100003CWHI NIH HHS HHSN268201100004C
6 · The paper itself

Abstract

purpose of the studyA comparison of longitudinal global cognitive functioning in women Veteran and non-Veteran participants in the Women's Health Initiative (WHI). DESIGN AND

methodsWe studied 7,330 women aged 65-79 at baseline who participated in the WHI Hormone Therapy Trial and its ancillary Memory Study (WHIMS). Global cognitive functioning (Modified Mini-Mental State Examination [3MSE]) in Veterans (n = 279) and non-Veterans (n = 7,051) was compared at baseline and annually for 8 years using generalized linear modeling methods.

resultsCompared with non-Veterans, Veteran women were older, more likely to be Caucasian, unmarried, and had higher rates of educational and occupational attainment. Results of unadjusted baseline analyses suggest 3MSE scores were similar between groups. Longitudinal analyses, adjusted for age, education, ethnicity, and WHI trial assignment revealed differences in the rate of cognitive decline between groups over time, such that scores decreased more in Veterans relative to non-Veterans. This relative difference was more pronounced among Veterans who were older, had higher educational/occupational attainment and greater baseline prevalence of cardiovascular risk factors (e.g., smoking) and cardiovascular disease (e.g., angina, stroke). IMPLICATIONS: Veteran status was associated with higher prevalence of protective factors that may have helped initially preserve cognitive functioning. However, findings ultimately revealed more pronounced cognitive decline among Veteran relative to non-Veteran participants, likely suggesting the presence of risks that may impact neuropathology and the effects of which were initially masked by Veterans' greater cognitive reserve.

Indexed as

Women's HealthAgedAgingCognitionCognition DisordersFemaleHumansMemoryNeuropsychological TestsPrevalenceRetrospective StudiesRisk FactorsUnited StatesVeteransCognitionCognitive declineRisk factorsVeteransWomen

Identifiers

PMID26615021
PMCPMC4906317
OpenAlexW2177975007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.