ArticleExperimental eye research2016
Integrative properties of retinal ganglion cell electrical responsiveness depend on neurotrophic support and genotype in the mouse.
Article in Experimental eye research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Anesthetic effects on electrophysiological responses across the visual pathway.Scientific reports · 2024Article
- Using Noninvasive Electrophysiology to Determine Time Windows of Neuroprotection in Optic Neuropathies.International journal of molecular sciences · 2022Article
- Oral administration of a dual ETMolecular vision · 2022Article
- Review
- Adaptable retinal ganglion cell function: assessing autoregulation of inner retina pathways.Neural regeneration research · 2020Article
- Transgenic inhibition of astroglial NF-κB restrains the neuroinflammatory and neurodegenerative outcomes of experimental mouse glaucoma.Journal of neuroinflammation · 2020Article
- Article
- Segmental outflow of aqueous humor in mouse and human.Experimental eye research · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Early stages of glaucoma and optic neuropathies are thought to show inner retina remodeling and functional changes of retinal ganglion cells (RGCs) before they die. To assess RGC functional plasticity, we investigated the contrast-gain control properties of the pattern electroretinogram (PERG), a sensitive measure of RGC function, as an index of spatio-temporal integration occurring in the inner retina circuitry subserving PERG generators. We studied the integrative properties of the PERG in mice exposed to different conditions of neurotrophic support. We also investigated the effect of genotypic differences among mouse strains with different susceptibility to glaucoma (C57BL/6J, DBA/2J, DBA/2.Gpnmb(+)). Results show that the integrative properties of the PERG recorded in the standard C57BL/6J inbred mouse strain are impaired after deficit of neurotrophic support and partially restored after exogenous neurotrophic administration. Changes in PERG amplitude, latency, and contrast-dependent responses differ between mouse strains with different susceptibility to glaucoma. Results represent a proof of concept that the PERG could be used as a tool for in-vivo monitoring of RGC functional plasticity before RGC death, the effect of neuroactive treatments, as well as for high-throughput tool for phenotypic screening of different mouse genotypes.
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Registered trials
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