ArticleBosnian journal of basic medical sciences2015
Serum leptin, bone mineral density and the healing of long bone fractures in men with spinal cord injury.
Article in Bosnian journal of basic medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- The relationship between adipokine levels and bone mass-A systematic review.Endocrinology, diabetes & metabolism · 2023Pooled it
- Effects of high-fat diet-induced obesity on circulating bone turnover markers in mice: a meta-analysis.Frontiers in physiology · 2026Review
- Review
- Review
- Review of Secondary Causes of Osteoporotic Fractures Due to Diabetes and Spinal Cord Injury.Current osteoporosis reports · 2020Review
- Gene expression changes are associated with severe bone loss and deficient fracture callus formation in rats with complete spinal cord injury.Spinal cord · 2020Article
- Prevention and management of osteoporosis and osteoporotic fractures in persons with a spinal cord injury or disorder: A systematic scoping review.The journal of spinal cord medicine · 2019Article
- Surgical management of lower limb fractures in patients with spinal cord injury less associated with complications than non-operative management: A retrospective series of cases.The journal of spinal cord medicine · 2019Article
- Leptin Influences Healing in the Sprague Dawley Rat Fracture Model.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Effect of leptin combined with CoCl2 on healing in Sprague Dawley Rat fracture model.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previously reported fracture rates in patients with spinal cord injury range from 1% to 20%. However, the exact role of spinal cord injury in bone metabolism has not yet been clarified. In order to investigate the effects of serum leptin and bone mineral density on the healing of long bone fractures in men with spinal cord injury, 15 male SCI patients and 15 matched controls were involved in our study. The outcome indicated that at 4 and 8 weeks after bone fracture, callus production in patients with spinal cord injury was lower than that in controls. Besides, bone mineral density was significantly reduced at 2, 4 and 8 weeks. In addition, it was found that at each time point, patients with spinal cord injury had significantly higher serum leptin levels than controls and no association was found between serum leptin level and bone mineral density of lumbar vertebrae. Moreover, bone mineral density was positively correlated with bone formation in both of the groups. These findings suggest that in early phases i.e. week 4 and 8, fracture healing was impaired in patients with spinal cord injury and that various factors participated in the complicated healing process, such as hormonal and mechanical factors.
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Registered trials
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