ArticleGenetics2016
Genetic Architectures of Quantitative Variation in RNA Editing Pathways.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Distinct genetic architecture of gene and isoform level QTL in the Diversity Outbred (DO) mouse population.bioRxiv : the preprint server for biology · 2026Article
- Fifteen years of the Diversity Outbred mouse model: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- irCLASH reveals RNA substrates recognized by human ADARs.Nature structural & molecular biology · 2020Article
- Genetic factors contributing to extensive variability of sex-specific hepatic gene expression in Diversity Outbred mice.PloS one · 2020Article
- The evolving role of Fourier-transform mid-infrared spectroscopy in genetic improvement of dairy cattle.Journal of animal science and biotechnology · 2020Review
- Sex-Biased lncRNAs Inversely Correlate With Sex-Opposite Gene Coexpression Networks in Diversity Outbred Mouse Liver.Endocrinology · 2019Article
- WidespreadRNA (New York, N.Y.) · 2019Article
- Article
- The landscape of the A-to-I RNA editome from 462 human genomes.Scientific reports · 2018Article
- Linkage of A-to-I RNA Editing in Metazoans and the Impact on Genome Evolution.Molecular biology and evolution · 2018Article
- Population and allelic variation of A-to-I RNA editing in human transcriptomes.Genome biology · 2017Article
- Loci Contributing to Boric Acid Toxicity in Two Reference Populations ofG3 (Bethesda, Md.) · 2017Article
- APOBEC1 complementation factor (A1CF) is dispensable for C-to-U RNA editing in vivo.RNA (New York, N.Y.) · 2017Article
- The Importance of ncRNAs as Epigenetic Mechanisms in Phenotypic Variation and Organic Evolution.Frontiers in microbiology · 2017Review
- Testicular adenosine to inosine RNA editing in the mouse is mediated by ADARB1.Biology of reproduction · 2017Article
- Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection.G3 (Bethesda, Md.) · 2016Article
- Reverse Transcription Errors and RNA-DNA Differences at Short Tandem Repeats.Molecular biology and evolution · 2016Article
- Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
RNA editing refers to post-transcriptional processes that alter the base sequence of RNA. Recently, hundreds of new RNA editing targets have been reported. However, the mechanisms that determine the specificity and degree of editing are not well understood. We examined quantitative variation of site-specific editing in a genetically diverse multiparent population, Diversity Outbred mice, and mapped polymorphic loci that alter editing ratios globally for C-to-U editing and at specific sites for A-to-I editing. An allelic series in the C-to-U editing enzyme Apobec1 influences the editing efficiency of Apob and 58 additional C-to-U editing targets. We identified 49 A-to-I editing sites with polymorphisms in the edited transcript that alter editing efficiency. In contrast to the shared genetic control of C-to-U editing, most of the variable A-to-I editing sites were determined by local nucleotide polymorphisms in proximity to the editing site in the RNA secondary structure. Our results indicate that RNA editing is a quantitative trait subject to genetic variation and that evolutionary constraints have given rise to distinct genetic architectures in the two canonical types of RNA editing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.