ArticleJournal of neuro-oncology2016
Increased diffusion in the normal appearing white matter of brain tumor patients: is this just tumor infiltration?
Article in Journal of neuro-oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Microstructural Abnormalities in the Contralateral Normal-appearing White Matter of Glioblastoma Patients Evaluated with Advanced Diffusion Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2024Article
- Accurate low and high grade glioma classification using free water eliminated diffusion tensor metrics and ensemble machine learning.Scientific reports · 2024Article
- Prognostic Value of Apparent Diffusion Coefficient (ADC) in Patients with Diffuse Gliomas.Cancers · 2024Article
- Paediatric supratentorial tumours do not cause microstructural alterations in contralateral white matter: a preliminary study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Diffusion along the perivascular space as a potential biomarker for glioma grading and isocitrate dehydrogenase 1 mutation status prediction.Quantitative imaging in medicine and surgery · 2023Article
- Can machine learning models improve early detection of brain metastases using diffusion weighted imaging-based radiomics?Quantitative imaging in medicine and surgery · 2023Article
- Analysis of DWI in the classification of glioma pathology and its therapeutic application in clinical surgery: a case-control study.Translational cancer research · 2022Article
- Advanced Magnetic Resonance Imaging Techniques in Management of Brain Metastases.Frontiers in oncology · 2019Review
- Value of diffusion kurtosis imaging in assessing low-grade gliomas.Journal of magnetic resonance imaging : JMRI · 2018Article
- Glioblastoma (GBM) effects on quantitative MRI of contralateral normal appearing white matter.Journal of neuro-oncology · 2018Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Altered diffusion in the normal appearing white matter (NAWM) of glioma patients has been explained by tumor infiltration. The goal of the present study was to test this explanation indirectly by examining whether these alterations were also present in the contralateral NAWM of non-infiltrative tumors like meningiomas; and to search for other possible reasons for this abnormality. Twenty-seven patients with histologically verified glioma (grade II-IV), 22 meningioma patients and two groups of age- and sex-matched healthy controls underwent diffusion weighted imaging (DWI) on a 3T MR. All patients were examined before treatment. Apparent diffusion coefficient (ADC) values were calculated in the entire NAWM of the hemisphere contralateral to the tumor. ADC values of the NAWM were compared between groups with Mann-Whitney U-test and multiple linear regression. The relations of ADC in NAWM to glioma grade and to tumor volume were also investigated. ADC values of the contralateral NAWM were significantly higher in both glioma and meningioma patients compared to controls (P = 0.0006 and 0.0099, respectively). ADC value was higher in the NAWM of high grade gliomas than in low grade gliomas (P = 0.0181) and in healthy control subjects (P = 0.0003). ADC did not depend on tumor volume in any of the patient groups. Elevated ADC in the NAWM of both glioma and meningioma patients might indicate that the effect of infiltrating tumor cells is not the only reason for the alteration as it has been previously suggested. Although the role of mass effect was not proved, other mechanisms might also contribute to ADC elevation.
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