Evidence map›Paper›PMID 26614512›Full record

ArticleMolecular neurobiology2016

IL-1β Is Involved with the Generation of Pain in Experimental Autoimmune Encephalomyelitis.

David Henrique Rodrigues, Bruno Pereira Leles, Vivian Vasconcelos Costa, Aline Silva Miranda, Daniel Cisalpino, Dawidson Assis Gomes, Danielle Glória de Souza, Antônio Lúcio Teixeira

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

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  4. Review
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  8. CaMKIIα Mediates the Effect of IL-17 To Promote Ongoing Spontaneous and Evoked Pain in Multiple Sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

David Henrique RodriguesDepartment of Basic and Health Sciences, Universidade Federal de Juiz de Fora-campus Governador Valadares, de Juiz de Fora, Brazil. dhenrodrigues@gmail.com.
Bruno Pereira LelesDepartment of Biochemistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Vivian Vasconcelos CostaDepartment of Biochemistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Aline Silva MirandaTranslational Psychoneuroimmunology Group, Laboratory of Immunopharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Daniel CisalpinoDepartment of Biochemistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Dawidson Assis GomesDepartment of Biochemistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Danielle Glória de SouzaDepartment of Biochemistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil.
Antônio Lúcio TeixeiraTranslational Psychoneuroimmunology Group, Laboratory of Immunopharmacology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade Federal de Juiz de Fora · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pain is one of the main symptoms of multiple sclerosis, a demyelinating disease of the central nervous system that affects millions of people worldwide. The experimental autoimmune encephalomyelitis (EAE) is considered an experimental model of multiple sclerosis, and besides motor weakness, hypernociception is one of the clinical signs of animals with EAE. In this study, we investigated the influence of some cytokines in the generation of the hypernociceptive response in a mouse model of EAE using MOG

Indexed as

AnimalsChemokine CXCL1Encephalomyelitis, Autoimmune, ExperimentalFemaleGanglia, SpinalInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinMice, Inbred C57BLMyelin-Oligodendrocyte GlycoproteinNAV1.8 Voltage-Gated Sodium ChannelNociceptionPainRNA, MessengerSpinal CordTRPV Cation ChannelsTumor Necrosis Factor-alphaChemokine CXCL1Cxcl1 protein, mouseInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinMyelin-Oligodendrocyte GlycoproteinNAV1.8 Voltage-Gated Sodium ChannelRNA, MessengerScn10a protein, mouseTRPV1 protein, mouseTRPV Cation ChannelsTumor Necrosis Factor-alphaCytokinesDorsal root gangliaExperimental autoimmune encephalomyelitisHypernociception

Identifiers

PMID26614512
OpenAlexW2175069657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.