Evidence map›Paper›PMID 26614186›Full record

ArticleThe international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease2015

Pott's disease in Moroccan children: clinical features and investigation of the interleukin-12/interferon-γ pathway.

S El Azbaoui, N Alaoui Mrani, A Sabri, Z Jouhadi, F Ailal, A A Bousfiha, J Najib, N El Hafidi, C Deswarte, E Schurr and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

S El AzbaouiGenetics Unit, Military Hospital Mohamed V, Hay Riad, Rabat, Morocco; Faculty of Science-Kenitra, Ibn Tofail University, Kenitra, Morocco.
N Alaoui MraniDepartment of Paediatric Surgery, Rabat Children Hospital, Medical and Pharmacy School of Rabat, Mohamed V University, Rabat, Morocco.
A SabriGenetics Unit, Military Hospital Mohamed V, Hay Riad, Rabat, Morocco; Faculty of Science-Kenitra, Ibn Tofail University, Kenitra, Morocco.
Z JouhadiDepartment of Paediatric Infectious Diseases, Ibn Rochd Hospital University Centre, King Hassan II University, Casablanca, Morocco.
F AilalDepartment of Paediatric Infectious Diseases, Ibn Rochd Hospital University Centre, King Hassan II University, Casablanca, Morocco.
A A BousfihaDepartment of Paediatric Infectious Diseases, Ibn Rochd Hospital University Centre, King Hassan II University, Casablanca, Morocco.
J NajibDepartment of Paediatric Infectious Diseases, Ibn Rochd Hospital University Centre, King Hassan II University, Casablanca, Morocco.
N El HafidiDepartment of Paediatrics, Medical and Pharmacy School of Rabat, Rabat Children Hospital, Rabat, Morocco.
C DeswarteLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale Unit 1163, Paris, France.
E SchurrMcGill International TB Centre, The Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
J BustamanteLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale Unit 1163, Paris, France; Imagine Institute, Paris Descartes University, Paris, France; Centre for the Study of Primary Immunodeficiencies, Assistance Publique-Hôpitaux de Paris, Necker Hospital for Sick Children, Paris, France.
S Boisson-DupuisLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale Unit 1163, Paris, France; Imagine Institute, Paris Descartes University, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, USA.
J-L CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale Unit 1163, Paris, France; Imagine Institute, Paris Descartes University, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, USA; Howard Hughes Medical Institute, New York, New York, USA; Paediatric Haematology-Immunology Unit, Necker Hospital for Sick Children, Paris, France, France.
L AbelDepartment of Paediatrics, Medical and Pharmacy School of Rabat, Rabat Children Hospital, Rabat, Morocco; Imagine Institute, Paris Descartes University, Paris, France; St Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, USA.
J El BaghdadiGenetics Unit, Military Hospital Mohamed V, Hay Riad, Rabat, Morocco.

Funding

Transforming Translational Science and Education to Benefit Human HealthUL1TR000043 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY · 2012 to 2015
$26.8M
Genetic predisposition to tuberculosis in MoroccoU01AI088685 · NIAID · ROCKEFELLER UNIVERSITY · PI ABEL, LAURENT, CASANOVA, JEAN-LAURENT · 2010 to 2014
$3.3M
A genetic dissection of Mendelian susceptibility to mycobacterial diseases (MSMD)R01AI089970 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT · 2010 to 2014
$2.5M
European Research Council 268777Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR000043NIAID NIH HHS R01 AI089970NIAID NIH HHS R01AI089970NIAID NIH HHS U01 AI088685NIAID NIH HHS U01AI088685PHS HHS 8ULTR000043
6 · The paper itself

Abstract

settingTuberculosis spondylodiscitis (TS), or Pott's disease, an extra-pulmonary form of tuberculosis (TB), is rare and difficult to diagnose in children. Some cases of severe TB in children were recently explained by inborn errors of immunity affecting the interleukin-12/interferon-gamma (IL-12/IFN-γ) axis.

objectiveTo analyse clinical data on Moroccan children with TS, and to perform immunological and genetic explorations of the IL-12/IFN-γ axis.

designWe studied nine children with TS diagnosed between 2012 and 2014. We investigated the IL-12/IFN-γ circuit by both whole-blood assays and sequencing of the coding regions of 14 core genes of this pathway.

resultsA diagnosis of TS was based on a combination of clinical, biological, histological and radiological data. QuantiFERON(®)-TB Gold In-Tube results were positive in 75% of patients. Whole-blood assays showed normal IL-12 and IFN-γ production in all but one patient, who displayed impaired decreased response to IL-12. No candidate disease-causing mutations were detected in the exonic regions of the 14 genes.

conclusionsTS diagnosis in children remains challenging, and is based largely on imaging. Further investigations of TS in children are required to determine the role of genetic defects in pathways that may or may not be related to the IL-12/IFN-γ axis.

Indexed as

AdolescentChildChild, PreschoolDrug TherapyFemaleHumansInterferon-gammaInterleukin-12Magnetic Resonance ImagingMaleMoroccoMycobacterium tuberculosisProspective StudiesTomography, X-Ray ComputedTuberculin TestTuberculosis, SpinalIFNG protein, humanInterferon-gammaInterleukin-12

Identifiers

PMID26614186
PMCPMC4959462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.