Evidence map›Paper›PMID 26614030›Full record

ReviewThe Urologic clinics of North America2016

Pharmacogenomics: Biomarker-Directed Therapy for Bladder Cancer.

Robert T Jones, Kenneth M Felsenstein, Dan Theodorescu

Abstract readReview
In one paragraph

Review in The Urologic clinics of North America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Enhanced Expression ofFrontiers in genetics · 2021
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Robert T JonesUniversity of Colorado Cancer Center, Aurora, CO, USA; Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO, USA.
Kenneth M FelsensteinUniversity of Colorado Cancer Center, Aurora, CO, USA; Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO, USA.
Dan TheodorescuUniversity of Colorado Cancer Center, Aurora, CO, USA; Medical Scientist Training Program, University of Colorado School of Medicine, Aurora, CO, USA. Electronic address: dan.theodorescu@ucdenver.edu.
University of Colorado Cancer Center · USUniversity of Colorado Denver · US

Funding

Medical Scientist Training ProgramT32GM008497 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI WILSON, CARA C. · 1993 to 2022
$15.2M
Regulation and Targeting of CD24 in Bladder CancerR01CA075115 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI THEODORESCU, DAN · 2003 to 2024
$7.0M
PREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM007635 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI DELL'ACQUA, MARK L · 1985 to 2023
$6.1M
NCI NIH HHS R01 CA075115NIGMS NIH HHS T32 GM007635NIGMS NIH HHS T32 GM008497
6 · The paper itself

Abstract

The clinical management of bladder cancer has seen little change over the last three decades and there is pressing need to identify more effective treatments for advanced disease. Low clinical use of neoadjuvant therapies stems from historical limitations in the ability to predict patients most likely to respond to combination chemotherapies. This article focuses on recent molecular and genetic studies, highlighting promising clinical trials and retrospective studies, and discusses emerging trials that use predictive biomarkers to match patients with therapies to which they are most likely to respond. The implementation of predictive genomic and molecular biomarkers will revolutionize urologic oncology and the clinical management of bladder cancer.

Indexed as

PharmacogeneticsBiomarkers, TumorHumansImmunotherapyMolecular Targeted TherapyNeoadjuvant TherapyPrecision MedicinePredictive Value of TestsUrinary Bladder NeoplasmsBiomarkers, TumorBladder cancerClinical trialsImmunotherapyMolecular subtypePersonalized medicinePharmacogenomicsPrecision medicinePredictive biomarker

Identifiers

PMID26614030
PMCPMC4663013
OpenAlexW2174708069

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.