ArticleMolecular systems biology2015
Signaling output: it's all about timing and feedbacks.
Article in Molecular systems biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed.
- Mitogen signaling strength and duration can control cell cycle decisions.Science advances · 2024Review
- Sustained intestinal epithelial monolayer wound closure after transient application of a FAK-activating small molecule.PloS one · 2024Article
- Real-time sensing of MAPK signaling in medulloblastoma cells reveals cellular evasion mechanism counteracting dasatinib blockade of ERK activation during invasion.Neoplasia (New York, N.Y.) · 2020Article
- The extracellular matrix as a key regulator of intracellular signalling networks.British journal of pharmacology · 2019Review
- Network Modeling Unravels Mechanisms of Crosstalk between Ethylene and Salicylate Signaling in Potato.Plant physiology · 2018Article
- Tissue-specific tumorigenesis: context matters.Nature reviews. Cancer · 2017Review
- Sampling-based Bayesian approaches reveal the importance of quasi-bistable behavior in cellular decision processes on the example of the MAPK signaling pathway in PC-12 cell lines.BMC systems biology · 2017Article
- Signaling output: it's all about timing and feedbacks.Molecular systems biology · 2015Article
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1 author.
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Abstract
The central questions in understanding signaling pathway specificity are how these pathways encode which stimulus is present and how this stimulus is decoded to yield the correct cell fate decision. In their recent work, Ryu et al (2015) show by stimulation experiments with different ligands how the differential engagement of feedback and feed-forward regulation leads to different dynamics of pathway activity, which in turn alters cell fate.Moreover, they show that by considering the timescales of the feedback regulations,the different cellular responses can be triggered with pulsed stimulations by a single ligand.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.