Evidence map›Paper›PMID 26613928›Full record

ReviewThe neuroradiology journal2016

Magnetic resonance imaging and magnetic resonance spectroscopy in a young male patient with anti-N-methyl-D-aspartate receptor encephalitis and uncommon cerebellar involvement: A case report with review of the literature.

Alessandra Splendiani, Valentina Felli, Alessandra Di Sibio, Antonio Gennarelli, Lucia Patriarca, Paolo Stratta, Ernesto Di Cesare, Alessandro Rossi, Gallucci Massimo

Open access · greenAbstract readCase ReportsReview
In one paragraph

Review in The neuroradiology journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. High-grade gliomas with autoimmune encephalitis-like presentation: case report and systematic review of the literature.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
  2. Journal of neurology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alessandra SplendianiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy alessandra.splendiani@cc.univaq.it.
Valentina FelliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Alessandra Di SibioDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Antonio GennarelliDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Lucia PatriarcaDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Paolo StrattaDepartment of Mental Health, S. Salvatore Hospital, 67100, L'Aquila, Italy.
Ernesto Di CesareDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Alessandro RossiDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
Gallucci MassimoDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.
University of L'Aquila · ITSan Salvatore Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a 17-year-old man presenting with new onset psychiatric symptoms. Magnetic resonance imaging (MRI) and proton magnetic resonance (MR) spectroscopy revealed some lesions in the right cerebellar hemisphere and ipsilateral cerebellar tonsil suggestive of encephalitis. An extensive workup was negative for both infectious and neoplastic diseases and he was afterward diagnosed with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. This disorder is an autoimmune encephalitis, highly lethal but curable, predominantly found in young female with ovarian teratoma. He received methylprednisolone. His clinical findings gradually improve and he made a complete recovery. Accordingly, repeated brain MRI and proton MR spectroscopy showed a gradual reduction of the lesions; MRI taken six months after starting therapy showed complete resolution of the lesions. Our case shows that, although rare, anti-NMDAR encephalitis should be considered also in young men for whom a rapid onset of psychiatric neurological disorders cannot be explained by more frequent causes. Our report underlines also the usefulness of MRI and proton MR spectroscopic findings in the diagnosis and follow-up of this disease.

Indexed as

AdultAnti-Inflammatory AgentsAnti-N-Methyl-D-Aspartate Receptor EncephalitisAspartic AcidBiomarkersCerebellumDiagnosis, DifferentialHumansMagnetic Resonance ImagingMaleMethylprednisoloneProton Magnetic Resonance SpectroscopyTreatment OutcomeAnti-Inflammatory AgentsAspartic AcidBiomarkersMethylprednisoloneN-acetylaspartateanti-NMDAR encephalitisMagnetic Resonance ImagingMagnetic Resonance spectroscopy

Identifiers

PMID26613928
PMCPMC4978334
OpenAlexW2176325173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.