ArticleJournal of pediatric surgery2016
Hematologic outcomes after total splenectomy and partial splenectomy for congenital hemolytic anemia.
Article in Journal of pediatric surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- The efficacy of partial versus total splenectomy in the treatment of hereditary spherocytosis in children: a systematic review and meta-analysis.Pediatric surgery international · 2024Pooled it
- Partial Splenectomy as a Definitive or Interim Solution for Young Children with Transfusion-dependent Hemolytic Anemia: Long-term Results from a 15-Year Cohort.Indian journal of pediatrics · 2026Article
- Subtotal Versus Total Splenectomy in Children With Sickle Cell Disease: Clinical Outcomes and Splenic Function Assessed by Pocked Red Blood Cell Count.American journal of hematology · 2026Article
- In silico biophysics and rheology of blood and red blood cells in Gaucher Disease.PLoS computational biology · 2025Article
- In silico biophysics and rheology of blood and red blood cells in Gaucher Disease.bioRxiv : the preprint server for biology · 2024Article
- Limits in Laparoscopic Partial Splenectomy in Children.Children (Basel, Switzerland) · 2022Article
- Diagnosis and clinical management of red cell membrane disorders.Hematology. American Society of Hematology. Education Program · 2021Article
- Role of Partial Splenectomy in Hematologic Childhood Disorders.Pathogens (Basel, Switzerland) · 2021Review
- Partial Splenectomy for a Sizeable Cavernous Hemangioma: Case Report and a Review of the Literature.Cureus · 2021Article
- Acute Splenic Sequestration Crisis in Hemoglobin SC Disease: Efficiency of Red Cell Exchange.Cureus · 2020Article
- Preventing infections in children and adults with asplenia.Hematology. American Society of Hematology. Education Program · 2020Article
- Review
- LONG-TERM HEMATOLOGIC AND CLINICAL OUTCOMES OF SPLENECTOMY IN CHILDREN WITH HEREDITARY SPHEROCYTOSIS AND SICKLE CELL DISEASE.Pediatric blood & cancer · 2020Article
- Clinical and laboratory outcomes following total or partial splenectomy in patients with hereditary spherocytosis.Pediatric hematology and oncology · 2019Article
- The Spectrum ofFrontiers in physiology · 2019Article
- Recommendations regarding splenectomy in hereditary hemolytic anemias.Haematologica · 2017Article
- Knowledge insufficient: the management of haemoglobin SC disease.British journal of haematology · 2017Review
- Laparoscopic Splenectomy Alone for Sickle Cell Disease: Account of 50 paediatric cases.Sultan Qaboos University medical journal · 2016Article
- Alteration of lymphocyte phenotype and function in sickle cell anemia: Implications for vaccine responses.American journal of hematology · 2016Review
Corrections and comments
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Authors and funding
36 authors at 17 institutions in 2 countries.
Funding
Abstract
purposeThe purpose of this study was to define the hematologic response to total splenectomy (TS) or partial splenectomy (PS) in children with hereditary spherocytosis (HS) or sickle cell disease (SCD).
methodsThe Splenectomy in Congenital Hemolytic Anemia (SICHA) consortium registry collected hematologic outcomes of children with CHA undergoing TS or PS to 1 year after surgery. Using random effects mixed modeling, we evaluated the association of operative type with change in hemoglobin, reticulocyte counts, and bilirubin. We also compared laparoscopic to open splenectomy.
resultsThe analysis included 130 children, with 62.3% (n=81) undergoing TS. For children with HS, all hematologic measures improved after TS, including a 4.1g/dl increase in hemoglobin. Hematologic parameters also improved after PS, although the response was less robust (hemoglobin increase 2.4 g/dl, p<0.001). For children with SCD, there was no change in hemoglobin. Laparoscopy was not associated with differences in hematologic outcomes compared to open. TS and laparoscopy were associated with shorter length of stay.
conclusionChildren with HS have an excellent hematologic response after TS or PS, although the hematologic response is more robust following TS. Children with SCD have smaller changes in their hematologic parameters. These data offer guidance to families and clinicians considering TS or PS.
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Registered trials
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