Trial reportClinical oral investigations2016
Interdental papilla loss: treatment by hyaluronic acid gel injection: a case series.
Trial report in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Effectiveness of Hyaluronic Acid Injection in the Reconstruction of Interdental Papilla: A Systematic Review.Oral health & preventive dentistry · 2025Pooled it
- The use of hyaluronic acid injection for treatment of black triangle and reconstruction of lost interdental papilla in anterior teeth: a systematic review.Acta odontologica Scandinavica · 2024Pooled it
- Interdental papilla reconstruction: a systematic review.Clinical oral investigations · 2024Pooled it
- Trial
- Trial
- Non-Surgical Cosmetic Treatment Modalities for Interdental Papilla Reconstruction "Black Triangles": An Evidence-Based Review.Journal of cosmetic dermatology · 2026Review
- Pink esthetic treatment of gingival recession, black triangle, and gummy smile: a narrative review.Maxillofacial plastic and reconstructive surgery · 2025Review
- A Review on the Expanding Role of Dentists in Facial Esthetics.Journal of pharmacy & bioallied sciences · 2024Review
- Exploratory study on a novel minimally invasive tunnel like flap approach for orthodontic movement of dental implants.Clinical oral investigations · 2024Article
- Histologic Evaluation of Early Papilla Healing after Augmentation with Injectable Hyaluronic Acid-A Proof of Concept.Journal of clinical medicine · 2024Article
- Evaluation of Interdental Papilla Regeneration Using Injectable Hyaluronic Acid: A Clinical Study.Cureus · 2024Article
- Biomechanical Considerations in the Orthodontic Treatment of a Patient with Stabilised Stage IV Grade C Generalised Periodontitis: A Case Report.Bioengineering (Basel, Switzerland) · 2024Article
- Comparison of the effect of albumin with platelet-rich fibrin (Alb-PRF) gel and hyaluronic acid gel injection on interdental papilla reconstruction: A randomized clinical trial.Journal of advanced periodontology & implant dentistry · 2024Article
- Investigating the efficacy of hyaluronic acid in minimizing black triangles: A comprehensive analysis.F1000Research · 2024Review
- Evaluation of the Effect of Hyaluronic Acid Injection on the Reconstruction of Reduced Interdental Papillae in Patients Referred to Shiraz School of Dentistry.Journal of dentistry (Shiraz, Iran) · 2023Article
- Food Impaction in Dentistry: Revisited.Oral health & preventive dentistry · 2023Review
- Effectiveness of Hyaluronic Acid Gel Injection with and without PRGF for Management of Interdental Papillary Loss: A Randomized Clinical Trial.Journal of functional biomaterials · 2023Article
- Application of Hyaluronic Acid for Treatment of Interdental Papillary Deficiency: A Systematic Review and Meta-Analysis.Frontiers in dentistry · 2023Article
- Papillary Reconstruction using Hyaluronic Acid: A Review.Oral health & preventive dentistry · 2022Review
- The efficacy of a new paste formulation as an alternative therapeutic agent for traumatic ulcers.Journal of Taibah University Medical Sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe purpose of this prospective clinical trial was to examine the clinical and patient outcomes following esthetic reconstruction of interdental papilla loss in anterior teeth, using an injectable, non-animal-based, hyaluronic acid gel. MATERIALS AND
methodsTen systemically healthy adults, with at least one anterior site with class I or II interdental papilla loss, were recruited. Following local anesthesia, ∼0.2 ml of hyaluronic acid gel was injected directly into the base of the papilla. The injection was repeated twice 21 days later. Patients were seen monthly for follow-up. Lost papilla surface area was calculated from digital clinical photographs taken at baseline and at 4 and 6 months postoperatively. Differences in lost papilla surface area between baseline and postoperative time points were statistically analyzed. Participants completed questionnaires (satisfaction surveys).
resultsSeventeen sites (13 maxillary, 4 mandibular) were treated in 9 females who completed the study. The lost inderdental papilla area at baseline and at the 4- and 6-month postoperative visits was 1.2 ± 1.8 mm(2) (mean ± SD), 0.6 ± 0.9 mm(2), and 0.7 ± 0.7 mm(2), respectively. Differences between baseline and postoperative visits were statistically significant (p < 0.0001). Two thirds of the patients would choose to undergo the procedure again.
conclusionsUse of hyaluronic acid gel to treat interdental papilla loss resulted in significant improvement at 6 months. Patients expressed satisfaction with the obtained improvement and dissatisfaction with the associated procedure discomfort. CLINICAL RELEVANCE: Treatment of interdental papilla loss (black triangle) by hyaluronic acid gel injection appears a promising modality to address this esthetic patient concern.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.