ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2016
Clinical characteristics of supine hypertension in de novo Parkinson disease.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 61 citations in OpenAlex.
- Association of blood pressure variability with white matter hyperintensities and nigrostriatal dopaminergic deficits in drug-naïve Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Should Neurogenic Supine Hypertension Be Treated? Insights from Hypertension-Mediated Organ Damage Studies-A Narrative Review.Biomedicines · 2025Review
- Enhanced visual illusions in Parkinson's disease with cardiovascular autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- The impact of short-term blood pressure variability on cognitive decline in Parkinson's disease patients without co-morbidities.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Review
- A 3-year natural history of orthostatic blood pressure dysregulation in early Parkinson's disease.NPJ Parkinson's disease · 2023Article
- Abnormal circadian blood pressure regulation and cognitive impairment in α-synucleinopathies.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Review
- Selected autonomic signs and symptoms as risk markers for phenoconversion and functional dependence in prodromal Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Advances in the Pathophysiology and Management of Supine Hypertension in Patients with Neurogenic Orthostatic Hypotension.Current hypertension reports · 2022Review
- Neurogenic Orthostatic Hypotension. Lessons From Synucleinopathies.American journal of hypertension · 2021Review
- Management Strategies for Comorbid Supine Hypertension in Patients with Neurogenic Orthostatic Hypotension.Current neurology and neuroscience reports · 2021Review
- Characterization of the changes in supine blood pressure with long-term use of droxidopa in patients with neurogenic orthostatic hypotension.Health science reports · 2021Article
- Autonomic Dysfunction in Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Clinical Trials for Neurogenic Orthostatic Hypotension: A Comprehensive Review of Endpoints, Pitfalls, and Challenges.Seminars in neurology · 2020Review
- Comparisons of cardiovascular dysautonomia and cognitive impairment between de novo Parkinson's disease and de novo dementia with Lewy bodies.BMC neurology · 2020Article
- Orthostatic Hypotension in Parkinson Disease.Clinics in geriatric medicine · 2020Review
- Treatment of Orthostatic Hypotension Due to Autonomic Dysfunction (Neurogenic Orthostatic Hypotension) in a Patient with Cardiovascular Disease and Parkinson's Disease.Cardiology and therapy · 2019Article
- Autonomic Dysfunction in α-Synucleinopathies.Frontiers in neurology · 2019Review
- Consensus statement on the definition of neurogenic supine hypertension in cardiovascular autonomic failure by the American Autonomic Society (AAS) and the European Federation of Autonomic Societies (EFAS) : Endorsed by the European Academy of Neurology (EAN) and the European Society of Hypertension (ESH).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2018Review
- Diagnosis of multiple system atrophy.Autonomic neuroscience : basic & clinical · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
purposeSupine hypertension is frequently associated with autonomic failure. However, its clinical characteristics in patients with Parkinson disease (PD) remain unclear. The present study aimed to clarify the characteristics of supine hypertension in patients with de novo PD.
methodsThe subjects were 72 patients with de novo PD. We studied blood pressure and plasma norepinephrine levels after the patients rested for 20 min in the supine position. Changes in blood pressure were also examined on head-up tilt-table testing.
resultsThe disease duration was 1.7 ± 1.6 years (average ± SD). Thirty-three (45.8 %) patients had supine hypertension (defined as a blood pressure of ≥140/90 mmHg). Supine blood pressure positively correlated with the degree of orthostatic hypotension. Age and the proportion of patients with akinetic-rigid motor subtype or preexisting hypertension were higher among patients with supine hypertension than among those without supine hypertension. The Mini-Mental State Examination score was lower in patients with supine hypertension than in those without supine hypertension. Sex, disease duration, disease severity, and peripheral sympathetic nervous activity as evaluated by the cardiac uptake of (123)I-metaiodobenzylguanidine and the plasma norepinephrine level did not differ between patients with and those without supine hypertension.
conclusionOlder age, akinetic-rigid motor subtype, and preexisting hypertension are independent risk factors for supine hypertension. Supine hypertension alone may be associated with milder peripheral sympathetic nervous denervation than orthostatic hypotension alone. As for global cognitive decline, supine hypertension is a far riskier comorbidity of early-stage PD than is orthostatic hypotension.
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