ArticleeLife2015
Maturation of metabolic connectivity of the adolescent rat brain.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
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- Aerobic exercise improves cognitive flexibility and modulates regional volume changes in a rat model of autism.Behavioural brain research · 2024Article
- Combination of fMRI and PET reveals the beneficial effect of three-phase enriched environment on post-stroke memory deficits by enhancing plasticity of brain connectivity between hippocampus and peri-hippocampal cortex.CNS neuroscience & therapeutics · 2024Article
- Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Single subanesthetic dose of ketamine produces delayed impact on brain [Frontiers in neuroscience · 2023Article
- Age-Related Changes in Topological Properties of Individual Brain Metabolic Networks in Rats.Frontiers in aging neuroscience · 2022Article
- Intracerebral Hemorrhage-Induced Cognitive Impairment in Rats Is Associated With Brain Atrophy, Hypometabolism, and Network Dysconnectivity.Frontiers in neuroscience · 2022Article
- Metabolic Brain Network Analysis WithFrontiers in neurology · 2021Article
- Changes in brain glucose metabolism and connectivity in somatoform disorders: anEuropean archives of psychiatry and clinical neuroscience · 2020Article
- Maturational delay and asymmetric information flow of brain connectivity in SHR model of ADHD revealed by topological analysis of metabolic networks.Scientific reports · 2020Article
- Clinical Personal Connectomics Using Hybrid PET/MRI.Nuclear medicine and molecular imaging · 2019Article
- Repeated social defeat induces transient glial activation and brain hypometabolism: A positron emission tomography imaging study.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Development of brain-wide connectivity architecture in awake rats.NeuroImage · 2018Article
- Increased Vesicular Monoamine Transporter 2 (VMAT2) and Dopamine Transporter (DAT) Expression in Adolescent Brain Development: A Longitudinal Micro-PET/CT Study in Rodent.Frontiers in neuroscience · 2018Article
- Dynamic brain glucose metabolism identifies anti-correlated cortical-cerebellar networks at rest.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Probing Intrinsic Resting-State Networks in the Infant Rat Brain.Frontiers in behavioral neuroscience · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging has been used to examine developmental changes of the brain. While PET studies revealed maturation-related changes, maturation of metabolic connectivity of the brain is not yet understood. Here, we show that rat brain metabolism is reconfigured to achieve long-distance connections with higher energy efficiency during maturation. Metabolism increased in anterior cerebrum and decreased in thalamus and cerebellum during maturation. When functional covariance patterns of PET images were examined, metabolic networks including default mode network (DMN) were extracted. Connectivity increased between the anterior and posterior parts of DMN and sensory-motor cortices during maturation. Energy efficiency, a ratio of connectivity strength to metabolism of a region, increased in medial prefrontal and retrosplenial cortices. Our data revealed that metabolic networks mature to increase metabolic connections and establish its efficiency between large-scale spatial components from childhood to early adulthood. Neurodevelopmental diseases might be understood by abnormal reconfiguration of metabolic connectivity and efficiency.
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