Evidence map›Paper›PMID 26613092›Full record

ArticleOpen forum infectious diseases2015

Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses.

Sabine Kinloch-de Loes, Lucy Dorrell, Hongbing Yang, Gareth A D Hardy, Sabine Yerly, Cristina Cellerai, Linos Vandekerckhove, Ward De Spielgelaere, Eva Malatinkova, Willie Wee Lee Koh and 1 more

Abstract read
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In one paragraph

Article in Open forum infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sabine Kinloch-de LoesDivision of Infection and Immunity , Royal Free Campus, University College London ; Royal Free Hospital , London ; Department of Immunology , University College London Medical School , Royal Free Campus.
Lucy DorrellNuffield Department of Medicine ; Oxford National Institute of Health Research Biomedical Research Centre , University of Oxford.
Hongbing YangNuffield Department of Medicine ; Oxford National Institute of Health Research Biomedical Research Centre , University of Oxford.
Gareth A D HardyCentre for Immunology and Virology , Imperial College London ; Chelsea and Westminster Hospital , London , United Kingdom.
Sabine YerlyLaboratory of Virology , Geneva University Hospital.
Cristina CelleraiDivision of Infection and Immunity , Royal Free Campus, University College London ; Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Linos VandekerckhoveHIV Translational Research Unit , Ghent University ; University Hospital Ghent , Belgium.
Ward De SpielgelaereHIV Translational Research Unit , Ghent University ; University Hospital Ghent , Belgium.
Eva MalatinkovaHIV Translational Research Unit , Ghent University ; University Hospital Ghent , Belgium.
Willie Wee Lee KohDepartment of Immunology and Molecular Pathology , University College London Medical School , University College London Campus , United Kingdom.
Margaret A JohnsonDivision of Infection and Immunity , Royal Free Campus, University College London ; Royal Free Hospital , London.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4(+)/CD8(+) T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.

Indexed as

antiretroviral therapyCD8 T cellHIV-1 reservoirprimary HIV-1 infectionviral inhibition assay

Identifiers

PMID26613092
PMCPMC4659693

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.