Evidence map›Paper›PMID 26613030›Full record

ArticleClinical kidney journal2015

Ambulatory blood pressure and tubulointerstitial injury in patients with IgA nephropathy.

Kotaro Haruhara, Nobuo Tsuboi, Kentaro Koike, Go Kanzaki, Yusuke Okabayashi, Yoichi Miyazaki, Tetsuya Kawamura, Makoto Ogura, Takashi Yokoo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Sodium excretion per nephron and nighttime hypertension in patients with IgA nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kotaro HaruharaDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.
Nobuo TsuboiDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.
Kentaro KoikeDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.
Go KanzakiDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.
Yusuke OkabayashiDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.
Yoichi MiyazakiDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.
Tetsuya KawamuraDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.
Makoto OguraDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.
Takashi YokooDivision of Nephrology and Hypertension, Department of Internal Medicine , Jikei University School of Medicine , Minato-Ku , Tokyo , Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies have been conducted to assess the ambulatory blood pressure (ABP) in IgA nephropathy (IgAN) patients. This study aimed to determine the relationships between ABP and renal histopathological findings assessed using the Oxford classification (OC) and the Japanese classification (JC), which have recently established histopathological criteria for IgAN.

methodsThis cross-sectional study included biopsy-diagnosed IgAN patients, in whom both a renal biopsy and ABP measurement were performed. The histopathological findings were assessed using the OC and the JC and were analyzed in relation to the ABP.

resultsA total of 111 IgAN patients were included. The score of interstitial fibrosis and tubular atrophy (T score) using the OC was a significantly associated factor with both the daytime and nighttime ABP values. In contrast, the other histopathological scores, including mesangial hypercellularity, endocapillary hypercellularity and segmental glomerulosclerosis, did not show significant associations with the ABP. The histological grade (H-grade) using the JC, which was based on the sum of injured glomeruli, was associated with the daytime ABP, but not with the nighttime ABP. The associations between the T score using the OC (%) and the daytime and nighttime ABP values were independent of age, gender, renal function, proteinuria and the use of antihypertensive medications, whereas the H-grade using the JC (%) did not show significant associations after adjusting for these clinical parameters.

conclusionsThese results suggest that the T score using the OC is the most relevant renal histopathological parameter associated with abnormalities of circadian blood pressure in IgAN patients.

Indexed as

ambulatory blood pressureIgA nephropathyOxford classificationrenal biopsytubulointerstitial fibrosis

Identifiers

PMID26613030
PMCPMC4655792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.