Evidence map›Paper›PMID 26613022›Full record

ArticleClinical kidney journal2015

Acute kidney injury risk assessment at the hospital front door: what is the best measure of risk?

Gareth Roberts, Dafydd Phillips, Rowan McCarthy, Hemanth Bolusani, Paul Mizen, Mohamed Hassan, Rachel Hooper, Kimberly Saddler, Mo Hu, Sonal Lodhi and 5 more

Open access · goldAbstract read
In one paragraph

Article in Clinical kidney journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  16. Serum uric acid and AKI: is it time?Clinical kidney journal · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 8 institutions in 1 country.

Gareth RobertsDepartment of Medicine , Aneurin Bevan University Health Board , Royal Gwent Hospital , Newport , UK.
Dafydd PhillipsInsititute of Nephrology , Cardiff University School of Medicine , Cardiff , UK.
Rowan McCarthyDepartment of Medicine , Cardiff and Vale University Health Board , University Hospital of Wales , Cardiff , UK.
Hemanth BolusaniDepartment of Medicine , Cardiff and Vale University Health Board , University Hospital of Wales , Cardiff , UK.
Paul MizenDepartment of Medicine , Aneurin Bevan University Health Board , Royal Gwent Hospital , Newport , UK.
Mohamed HassanDepartment of Medicine , Cwm Taf University Health Board Prince Charles Hospital , Merthyr Tydfil , UK.
Rachel HooperDepartment of Medicine , Cwm Taf University Health Board Prince Charles Hospital , Merthyr Tydfil , UK.
Kimberly SaddlerDepartment of Medicine , Cwm Taf University Health Board Prince Charles Hospital , Merthyr Tydfil , UK.
Mo HuDepartment of Medicine , Cardiff and Vale University Health Board, University Hospital Llandough , Cardiff , UK.
Sonal LodhiDepartment of Medicine , Cardiff and Vale University Health Board, University Hospital Llandough , Cardiff , UK.
Ella ToyntonDepartment of Medicine , Cardiff and Vale University Health Board, University Hospital Llandough , Cardiff , UK.
John GeenDepartment of Clinical Biochemistry, Cwm Taf University Health Board and Faculty of Life Sciences and Education , University of South Wales , Cardiff , UK.
Vikas LodhiDepartment of Medicine , Cardiff and Vale University Health Board, University Hospital Llandough , Cardiff , UK.
Catherine GroseDepartment of Medicine , Aneurin Bevan University Health Board , Royal Gwent Hospital , Newport , UK.
Aled PhillipsInsititute of Nephrology , Cardiff University School of Medicine , Cardiff , UK.
Cardiff and Vale University Health Board · GBAneurin Bevan University Health Board · GBCardiff University · GBCwm Taf University Health Board · GBPrince Charles Hospital · GBRoyal Gwent Hospital · GBUniversity Hospital Llandough · GBUniversity Hospital of Wales · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe examined the prevalence of acute kidney injury (AKI) risk factors in the emergency medical unit, generated a modified risk assessment tool and tested its ability to predict AKI.

methodsA total of 1196 patients admitted to medical admission units were assessed for patient-associated AKI risk factors. Subsequently, 898 patients were assessed for a limited number of fixed risk factors with the addition of hypotension and sepsis. This was correlated to AKI episodes.

resultsIn the first cohort, the prevalence of AKI risk factors was 2.1 ± 2.0 per patient, with a positive relationship between age and the number of risk factors and a higher number of risk factors in patients ≥65 years. In the second cohort, 12.3% presented with or developed AKI. Patients with AKI were older and had a higher number of AKI risk factors. In the AKI cohort, 72% of the patients had two or more AKI risk factors compared with 43% of the cohort with no AKI. When age ≥65 years was added as an independent risk factor, 84% of those with AKI had two or more AKI risk factors compared with 55% of those with no AKI. Receiver operating characteristic analysis suggests that the use of common patient-associated known AKI risk factors performs no better than age alone as a predictor of AKI.

conclusionsDetailed assessment of well-established patient-associated AKI risk factors may not facilitate clinicians to apportion risk. This suggests that additional work is required to develop a more sensitive validated AKI-predictive tool that would be useful in this clinical setting.

Indexed as

acute tubular necrosisAKIchronic renal failurechronic renal insufficiencyepidemiology

Identifiers

PMID26613022
PMCPMC4655789
OpenAlexW2231601316

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.