ArticleMetabolomics : Official journal of the Metabolomic Society
Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis.
Article in Metabolomics : Official journal of the Metabolomic Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 47 citations in OpenAlex.
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- Issues and challenges in diabetic neuropathy management: A narrative review.World journal of diabetes · 2023Review
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- Optimized integration of metabolomics and lipidomics reveals brain region-specific changes of oxidative stress and neuroinflammation in type 1 diabetic mice with cognitive decline.Journal of advanced research · 2023Article
- Bezafibrate Reduces Elevated Hepatic Fumarate in Insulin-Deficient Mice.Biomedicines · 2022Article
- Application of Metabolomics in Various Types of Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- A Contemporary Insight of Metabolomics Approach for Type 1 Diabetes: Potential for Novel Diagnostic Targets.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- Integrative analyses of TEDDY Omics data reveal lipid metabolism abnormalities, increased intracellular ROS and heightened inflammation prior to autoimmunity for type 1 diabetes.Genome biology · 2021Article
- Microbial Metabolomics: From Methods to Translational Applications.Advances in experimental medicine and biology · 2021Article
- Excretory/Secretory Metabolome of the Zoonotic Roundworm ParasiteBiomolecules · 2020Article
- Metabolomics Provide Sensitive Insights into the Impacts of Low Level Environmental Contamination on Fish Health-A Pilot Study.Metabolites · 2020Article
- Metabolite Changes in an Estuarine Annelid Following Sublethal Exposure to a Mixture of Zinc and Boscalid.Metabolites · 2019Article
- Using metabolomics to assess the sub-lethal effects of zinc and boscalid on an estuarine polychaete worm over time.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Metabolomic profiling of the excretory-secretory products of hookworm and whipworm.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- Characterization of Tapeworm Metabolites and Their Reported Biological Activities.Molecules (Basel, Switzerland) · 2019Article
- Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes.Infection and immunity · 2019Article
- Cord Blood CD8Frontiers in immunology · 2018Article
- Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection.Scientific reports · 2017Article
- Lipidomics in the Study of Hypertension in Metabolic Syndrome.Current hypertension reports · 2017Review
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early mechanisms regulating progression towards beta cell failure in type 1 diabetes (T1D) are poorly understood, but it is generally acknowledged that genetic and environmental components are involved. The metabolomic phenotype is sensitive to minor variations in both, and accordingly reflects changes that may lead to the development of T1D. We used two different extraction methods in combination with both liquid- and gas chromatographic techniques coupled to mass spectrometry to profile the metabolites in a transgenic non-diabetes prone C57BL/6 mouse expressing CD154 under the control of the rat insulin promoter (RIP) crossed into the immuno-deficient recombination-activating gene (RAG) knockout (-/-) C57BL/6 mouse, resembling the early stages of human T1D. We hypothesized that alterations in the metabolomic phenotype would characterize the early pathogenesis of T1D, thus metabolomic profiling could provide new insight to the development of T1D. Comparison of the metabolome of the RIP CD154 × RAG
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.