ArticleProceedings of SPIE--the International Society for Optical Engineering
Early Postnatal Myelin Content Estimate of White Matter via T1w/T2w Ratio.
Article in Proceedings of SPIE--the International Society for Optical Engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- Infant Brain Age Estimation With T1w/T2w Ratio MRI: A Myelination-Aware Deep Learning Approach.Journal of magnetic resonance imaging : JMRI · 2026Article
- Influence of standardized breath-holding instruction and practice on craniocaudal misregistration between the arterial and venous phases in preoperative abdominal contrast-enhanced computed tomography.Radiological physics and technology · 2026Article
- Towards quantitative intensity analysis of conventional T1-weighted images in multiple sclerosis.NeuroImage · 2025Article
- Age-related changes in myelin and myelin water quantified with short-TR adiabatic inversion-recovery (STAIR) sequences.NeuroImage. Clinical · 2025Article
- Association between T1w/T2w ratio in white matter and cognitive function in Alzheimer's disease.Scientific reports · 2024Article
- An attention-based context-informed deep framework for infant brain subcortical segmentation.NeuroImage · 2023Article
- Mapping myelin in white matter with T1-weighted/T2-weighted maps: discrepancy with histology and other myelin MRI measures.Brain structure & function · 2023Article
- Characterisation of the neonatal brain using myelin-sensitive magnetisation transfer imaging.Imaging neuroscience (Cambridge, Mass.) · 2023Article
- Automation of a Rule-based Workflow to Estimate Age from Brain MR Imaging of Infants and Children Up to 2 Years Old Using Stacked Deep Learning.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Article
- Cyto/myeloarchitecture of cortical gray matter and superficial white matter in early neurodevelopment: multimodal MRI study in preterm neonates.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- Empirical transmit field bias correction of T1w/T2w myelin maps.NeuroImage · 2022Article
- T1w/T2w Ratio and Cognition in 9-to-11-Year-Old Children.Brain sciences · 2022Article
- Article
- T1-Weighted/T2-Weighted Ratio Mapping at 5 Months Captures Individual Differences in Behavioral Development and Differentiates Infants at Familial Risk for Autism from Controls.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Comparisons between multi-component myelin water fraction, T1w/T2w ratio, and diffusion tensor imaging measures in healthy human brain structures.Scientific reports · 2019Article
- Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects.NeuroImage. Clinical · 2019Article
- Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and TScientific reports · 2018Article
- Advances in noninvasive myelin imaging.Developmental neurobiology · 2018Review
- White Matter Fiber-based Analysis of T1w/T2w Ratio Map.Proceedings of SPIE--the International Society for Optical Engineering · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeTo develop and evaluate a novel processing framework for the relative quantification of myelin content in cerebral white matter (WM) regions from brain MRI data via a computed ratio of T1 to T2 weighted intensity values. DATA: We employed high resolution (1mm
methodsWe developed a novel, yet relatively straightforward image processing framework for WM myelin content estimation based on earlier work by Glasser et al. We first co-register the structural MRI data to correct for motion. Then, background areas are masked out via a joint T1w and T2 foreground mask computed. Raw T1w/T2w-ratios images are computed next. For purpose of calibration across subjects, we first coarsely segment the fat-rich facial regions via an atlas co-registration. Linear intensity rescaling based on median T1w/T2w-ratio values in those facial regions yields calibrated T1w/T2w-ratio images. Mean values in lobar regions are evaluated using standard statistical analysis to investigate their interaction with age at scan.
resultsSeveral lobes have strongly positive significant interactions of age at scan with the computed T1w/T2w-ratio. Most regions do not show sex effects. A few regions show no measurable effects of change in myelin content change within the first few weeks of postnatal development, such as cingulate and CC areas, which we attribute to sample size and measurement variability.
conclusionsWe developed and evaluated a novel way to estimate white matter myelin content for use in studies of brain white matter development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.