Evidence map›Paper›PMID 26612864›Full record

ArticleNucleic acids research2016

DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts.

Maria D Paraskevopoulou, Ioannis S Vlachos, Dimitra Karagkouni, Georgios Georgakilas, Ilias Kanellos, Thanasis Vergoulis, Konstantinos Zagganas, Panayiotis Tsanakas, Evangelos Floros, Theodore Dalamagas and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 431 papers.

0numbers the graph read from it
0cells of the map it votes in
431citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

431 citing papers in PubMed, 780 citations in OpenAlex.

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  8. Computational Resources for Studying miRNA-lncRNA Interactions.Methods in molecular biology (Clifton, N.J.) · 2026
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371 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Maria D ParaskevopoulouDIANA-Lab, Department of Computer & Communication Engineering, University of Thessaly, 382 21, Volos, Greece Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521, Athens, Greece mparaskevopoulou@inf.uth.gr.
Ioannis S VlachosDIANA-Lab, Department of Computer & Communication Engineering, University of Thessaly, 382 21, Volos, Greece Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521, Athens, Greece Laboratory for Experimental Surgery and Surgical Research 'N.S. Christeas', Medical School of Athens, University of Athens, 11527, Greece.
Dimitra KaragkouniDIANA-Lab, Department of Computer & Communication Engineering, University of Thessaly, 382 21, Volos, Greece Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521, Athens, Greece.
Georgios GeorgakilasDIANA-Lab, Department of Computer & Communication Engineering, University of Thessaly, 382 21, Volos, Greece Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521, Athens, Greece.
Ilias Kanellos'Athena' Research and Innovation Center, 11524, Athens, Greece University of Peloponnisos, Department of Informatics and Telecommunications, 22100, Tripoli, Greece.
Thanasis Vergoulis'Athena' Research and Innovation Center, 11524, Athens, Greece.
Konstantinos Zagganas'Athena' Research and Innovation Center, 11524, Athens, Greece School of Electrical and Computer Engineering, NTUA, 15773 Zografou, Greece.
Panayiotis TsanakasUniversity of Peloponnisos, Department of Informatics and Telecommunications, 22100, Tripoli, Greece Greek Research and Technology Network (GRNET), Athens 11527, Greece.
Evangelos FlorosGreek Research and Technology Network (GRNET), Athens 11527, Greece.
Theodore Dalamagas'Athena' Research and Innovation Center, 11524, Athens, Greece dalamag@imis.athena-innovation.gr.
Artemis G HatzigeorgiouDIANA-Lab, Department of Computer & Communication Engineering, University of Thessaly, 382 21, Volos, Greece Hellenic Pasteur Institute, 127 Vasilissis Sofias Avenue, 11521, Athens, Greece 'Athena' Research and Innovation Center, 11524, Athens, Greece arhatzig@inf.uth.gr.
Athena Research and Innovation Center In Information Communication & Knowledge Technologies · GRUniversity of Thessaly · GRNational Infrastructures for Research and Technology - GRNET S.A · GRPasteur Hellenic Institute · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

microRNAs (miRNAs) are short non-coding RNAs (ncRNAs) that act as post-transcriptional regulators of coding gene expression. Long non-coding RNAs (lncRNAs) have been recently reported to interact with miRNAs. The sponge-like function of lncRNAs introduces an extra layer of complexity in the miRNA interactome. DIANA-LncBase v1 provided a database of experimentally supported and in silico predicted miRNA Recognition Elements (MREs) on lncRNAs. The second version of LncBase (www.microrna.gr/LncBase) presents an extensive collection of miRNA:lncRNA interactions. The significantly enhanced database includes more than 70 000 low and high-throughput, (in)direct miRNA:lncRNA experimentally supported interactions, derived from manually curated publications and the analysis of 153 AGO CLIP-Seq libraries. The new experimental module presents a 14-fold increase compared to the previous release. LncBase v2 hosts in silico predicted miRNA targets on lncRNAs, identified with the DIANA-microT algorithm. The relevant module provides millions of predicted miRNA binding sites, accompanied with detailed metadata and MRE conservation metrics. LncBase v2 caters information regarding cell type specific miRNA:lncRNA regulation and enables users to easily identify interactions in 66 different cell types, spanning 36 tissues for human and mouse. Database entries are also supported by accurate lncRNA expression information, derived from the analysis of more than 6 billion RNA-Seq reads.

Indexed as

Databases, Nucleic AcidAbstracting and IndexingAnimalsBinding SitesHumansMiceMicroRNAsRNA, Long NoncodingMicroRNAsRNA, Long Noncoding

Identifiers

PMID26612864
PMCPMC4702897
OpenAlexW2223740898

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.