Evidence map›Paper›PMID 26612784›Full record

ArticleIntegrative cancer therapies2016

A Chinese Decoction, Kuan-Sin-Yin, Improves Autonomic Function and Cancer-Related Symptoms of Metastatic Colon Cancer.

Tsai-Ju Chien, Chia-Yu Liu, Pin-Hao Ko, Chung-Hua Hsu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative cancer therapies, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Tsai-Ju ChienInstitute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan Oncology Department, Zhong-Xing Branch, Taipei City Hospital, Taipei, Taiwan.
Chia-Yu LiuInstitute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan Chinese Medicine and Lin-Sen Branch, Taipei City Hospital, Taipei, Taiwan.
Pin-Hao KoNational Taiwan University, Taipei, Taiwan.
Chung-Hua HsuInstitute of Traditional Medicine, National Yang-Ming University, Taipei, Taiwan Chinese Medicine and Lin-Sen Branch, Taipei City Hospital, Taipei, Taiwan owlherbs@yahoo.com.tw.
National Taiwan University · TWNational Yang Ming Chiao Tung University · TWNational Yang Ming Chiao Tung University · TWTaipei City Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundKuan-Sin-Yin (KSY) is a traditional Chinese medicine (TCM) decoction, which has been shown to have cytostatic effects on cancer cells and involved in the TCM theory of promoting yin-yang balance.Sonce many cancer patients suffer from autonomic dysfunction (AD), which correspond to yin-yang imbalance in TCM. The aim of this study is to evaluate the possible effect of KSY in metastatic colon cancer (mCRC) patients with AD.

methodsWe conducted a single-group experiment. Total 52 qualified patients were enrolled. Participants took the KSY daily for 2 weeks. The primary outcome was KSY efficacy as reflected in the heart rate variability (HRV) and electrical conductivity (µA) over 12 meridian points. Autonomic function was examined before and after the KSY intervention. The vagal and sympathetic tone were recorded by HRV; 12 meridian energies were measured using a meridian energy analysis device. Secondary outcomes were cancer-related symptoms and patient quality of life (QoL).

resultsThe results showed that the KSY intervention improved AD via increasing the vagal tone (HF: P = .041), but not the sympathetic tone (LF: P = .154); total autonomic activity was significantly enhanced (HRV activity: P = .013). Intriguingly, energy increased more over the yin meridian (P = .010) than over the yang meridian (P = .015). Cancer-related symptoms and QoL were significantly improved (P < .05).

conclusionThe safety and effectiveness of KSY in improving AD in mCRC patients are through regulating the vagal-sympathetic dynamic balance, which correspond to the TCM yin-yang concept of energy.

Indexed as

AdolescentAdultAgedAutonomic AgentsAutonomic Nervous System DiseasesChildChild, PreschoolColonic NeoplasmsFemaleHeart RateHumansInfantInfant, NewbornMaleMedicine, Chinese TraditionalMiddle AgedAutonomic Agentsautonomic dysfunctionautonomic nervous system diseasesheart rate variabilityKuan-Sin-Yintraditional Chinese medicineyin-yang

Identifiers

PMID26612784
PMCPMC5736084
OpenAlexW2259683034

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.