Evidence map›Paper›PMID 26612695›Full record

ArticleObesity surgery2016

Changes in Serum Fatty Acid Levels During the First Year After Bariatric Surgery.

Chenchen Lin, Villy Våge, Svein Are Mjøs, Olav Martin Kvalheim

Open access · hybridAbstract read
In one paragraph

Article in Obesity surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chenchen LinDepartment of Chemistry, University of Bergen, Bergen, Norway.
Villy VågeDepartment of Surgery, Voss Hospital, Bergen Health Trust, Voss, Norway.
Svein Are MjøsDepartment of Chemistry, University of Bergen, Bergen, Norway.
Olav Martin KvalheimDepartment of Chemistry, University of Bergen, Bergen, Norway. olav.kvalheim@kj.uib.no.
Helse Førde · NOUniversity of Bergen · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe have assessed the effects of laparoscopic sleeve gastrectomy (LSG) and biliopancratic diversion with a duodenal switch (BPDDS) on fatty acid (FA) levels in serum. In particular, we examine the impact of surgery on the ratio of the FAs eicosapentaenoic acid (EPA) to arachidonic acid (AA) which impacts, e.g., cardiovascular health. Our hypothesis is that LSG and BPDDS influence the FA levels but that BPDDS may have a more persistent impact since BPDSS superimposes intestinal malabsorption on gastric restriction.

methodsSerum samples after overnight fasting were collected 3 months and 1 day before surgery and 3 days, 3 months, and 12 months after surgery from 10 BPDDS patients and 23 LSG patients. The levels of 16 FAs were quantified by gas chromatography. Preoperative and postoperative concentrations of EPA and AA and the ratio of EPA to AA were compared by Wilcoxon signed-rank test corrected for multiple testing using false discovery rate.

resultsThe ratio of EPA/AA at each of the three postoperative sampling points was lower than at the two preoperative sampling points for BPDDS with p < 0.05 after correcting significance levels for multiple testing. For LSG, the ratio was lower with p < 0.05 at 3 days and at 3 months after surgery, but not after 12 months.

conclusionBoth LSG and BPDDS lower the ratio of EPA/AA significantly and below recommended values, but LSG patients resurge toward normal values after approximately 12 months, while BPDDS patients do not.

Indexed as

Weight LossAdultArachidonic AcidBiliopancreatic DiversionEicosapentaenoic AcidFemaleGastrectomyHumansLaparoscopyMaleObesity, MorbidPostoperative PeriodTreatment OutcomeArachidonic AcidEicosapentaenoic AcidBariatric surgeryBiliopancratic diversion with a duodenal switch (BPDDS)Laparoscopic sleeve gastrectomy (LSG)Ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA)Serum fatty acid levels

Identifiers

PMID26612695
PMCPMC4951502
OpenAlexW2265558305

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.