ReviewNature reviews. Drug discovery2016
Optogenetics enlightens neuroscience drug discovery.
Review in Nature reviews. Drug discovery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Optogenetics for Investigating and Targeting Hallmark Traits of Cancer.Biomolecules · 2026Review
- Transcranial Magneto-Acoustic Stimulation Protects Synaptic Rehabilitation from Amyloid-Beta Plaques via Regulation of Microglial Functions.International journal of molecular sciences · 2024Article
- Emerging optogenetics technologies in biomedical applications.Smart medicine · 2023Review
- Lateral hypothalamic leptin receptor neurons drive hunger-gated food-seeking and consummatory behaviours in male mice.Nature communications · 2023Article
- Optophysiology: Illuminating cell physiology with optogenetics.Physiological reviews · 2022Review
- Optogenetic modulation of electroacupuncture analgesia in a mouse inflammatory pain model.Scientific reports · 2022Article
- Optoelectronic Neural Interfaces Based on Quantum Dots.ACS applied materials & interfaces · 2022Review
- Highly Parallelized, Multicolor Optogenetic Recordings of Cellular Activity for Therapeutic Discovery Applications in Ion Channels and Disease-Associated Excitable Cells.Frontiers in molecular neuroscience · 2022Article
- Photoactivated adenylyl cyclases attenuate sepsis-induced cardiomyopathy by suppressing macrophage-mediated inflammation.Frontiers in immunology · 2022Article
- Steering Molecular Activity with Optogenetics: Recent Advances and Perspectives.Advanced biology · 2021Review
- Pharmacological plasticity-How do you hit a moving target?Pharmacology research & perspectives · 2019Review
- Optogenetics: Therapeutic spark in neuropathic pain.Bosnian journal of basic medical sciences · 2019Review
- A unified circuit for social behavior.Neurobiology of learning and memory · 2019Article
- Opportunities and challenges in psychopharmacology .Dialogues in clinical neuroscience · 2019Review
- Remote control of movement disorders using a photoactive adenosine AJournal of controlled release : official journal of the Controlled Release Society · 2018Article
- The promise and perils of causal circuit manipulations.Current opinion in neurobiology · 2018Review
- Connectomics of synaptic microcircuits: lessons from the outer retina.The Journal of physiology · 2017Review
- Bringing new dimensions to drug discovery screening: impact of cellular stimulation technologies.Drug discovery today · 2017Review
- Optical control of paineLife · 2017Article
- From Engrams to Pathologies of the Brain.Frontiers in neural circuits · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Optogenetics - the use of light and genetics to manipulate and monitor the activities of defined cell populations - has already had a transformative impact on basic neuroscience research. Now, the conceptual and methodological advances associated with optogenetic approaches are providing fresh momentum to neuroscience drug discovery, particularly in areas that are stalled on the concept of 'fixing the brain chemistry'. Optogenetics is beginning to translate and transit into drug discovery in several key domains, including target discovery, high-throughput screening and novel therapeutic approaches to disease states. Here, we discuss the exciting potential of optogenetic technologies to transform neuroscience drug discovery.
Indexed as
Identifiers
26612666What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.