Trial reportBMC musculoskeletal disorders2015
Complete twelve month bone remodeling with a bi-phasic injectable bone substitute in benign bone tumors: a prospective pilot study.
Trial report in BMC musculoskeletal disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02567084 (A Prospective, Longitudinal Patient Study on CERAMENT™|BONE VOID FILLER in Benign Bone Tumors), which is not on this map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Longitudinal Patient Study on CERAMENT™|BONE VOID FILLER in Benign Bone Tumors
Who cites it
27 citing papers in PubMed, 42 citations in OpenAlex.
- Successful glenoid defect management with antibiotic-eluting bone graft substitute following baseplate removal in two-stage revision reverse shoulder arthroplasty: a case report and surgical considerations.JSES reviews, reports, and techniques · 2026Article
- A Scoping Review of CERAMENT™ Applications in Orthopedic Surgery.Journal of clinical medicine · 2025Review
- Traumatic Fracture Treatment: Calcium Phosphate Bone Substitute Case-Control Study in Humerus, Radius, Tibia Fractures-Assessing Efficacy and Recovery Outcomes.Biomedicines · 2023Article
- Artificial Bone Graft Substitutes for Curettage of Benign and Low-Grade Malignant Bone Tumors: Clinical and Radiological Experience with Cerasorb.Indian journal of orthopaedics · 2023Article
- Outcome of surgical interventions for solitary enchondromas of the hand : Controversial issues.Orthopadie (Heidelberg, Germany) · 2023Article
- Article
- Injection of a Bone Substitute in the Treatment of Unicameral Bone Cysts.Advances in orthopedics · 2023Article
- Systemic rifampicin shows accretion to locally implanted hydroxyapatite particles in a rat abdominal muscle pouch model.Journal of bone and joint infection · 2023Article
- Biphasic bone graft substitute in revision total hip arthroplasty with significant acetabular bone defects : a retrospective analysis.Bone & joint open · 2022Article
- An Observational Prospective Clinical Study for the Evaluation of a Collagen-Hydroxyapatite Composite Scaffold in Hip Revision Surgery.Journal of clinical medicine · 2022Article
- Treatment of benign bone lesions with an injectable biphasic bone substitute.BMC musculoskeletal disorders · 2022Article
- Article
- Application of osteoinductive calcium phosphate ceramics in giant cell tumor of the sacrum: report of six cases.Regenerative biomaterials · 2022Article
- Minimum 10 years clinical and radiological outcomes of acetabular revisions of total hip arthroplasties with tricalcium phosphate/hydroxyapatite bone graft substitute.BMC musculoskeletal disorders · 2021Article
- Imaging following surgery for primary appendicular bone tumours.Skeletal radiology · 2021Review
- Test yourself answer: supra-acetabular pelvis synthetic bone graft substitute (CERAMENT) with expected resorption of radiopaque graft material.Skeletal radiology · 2020Article
- Article
- Radiographic and Histological Analysis of a Synthetic Bone Graft Substitute Eluting Gentamicin in the Treatment of Chronic Osteomyelitis.Journal of bone and joint infection · 2019Article
- Calcium Sulphate/Hydroxyapatite Carrier for Bone Formation in the Femoral Neck of Osteoporotic Rats.Tissue engineering. Part A · 2018Article
- Early Clinical and Radiological Experience with a Ceramic Bone Graft Substitute in the Treatment of Benign and Borderline Bone Lesions.Scientific reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBenign primary bone tumors are commonly treated by surgery involving bone grafts or synthetic bone void fillers. Although synthetic bone grafts may provide early mechanical support while minimizing the risk of donor-site morbidity and disease transmission, difficult handling properties and less than optimal transformation to bone have limited their use.
methodsIn a prospective series, patients with benign bone tumors were treated by minimal invasive intervention with a bi-phasic and injectable ceramic bone substitute (CERAMENT™ BONE VOID FILLER, BoneSupport, Sweden) with the hypothesis that open surgery with bone grafting might be avoided. The defects were treated by either mini-invasive surgery (solid tumors) or percutaneous injection (cysts) and followed clinically and radiologically for 12 months. CT scan was performed after 12 months to confirm bone remodeling of the bone substitute. All patients were allowed full weight bearing immediately after surgery.
resultsFourteen patients with a median age of 13 years (range 7-75) were consecutively recruited during 11 months. Eleven lesions were bone cysts (eight unicameral and three post-traumatic) and three were solid benign tumors. The median size of the lesions was 40 mL (range 1-152). The most common location was humerus (n = 10). After 12 months the defects completely or partially filled with median 18 mL (range 5-28) of bone substitute demonstrated full resolution (Neer Classification grade I) in 11 patients, partial resolution (Neer II) in 2 patients and in 1 patient the cyst persisted (Neer III). No lesions required recurrent surgery during the observation period. No post-operative fracture or infection was recorded.
conclusionsMinimal invasive treatment with a bi-phasic and injectable ceramic bone substitute might offer an alternative to regular bone grafting due to convenient handling properties and rapid bone remodeling.
trial registrationClinicalTrials NCT02567084 Release Date 10/01/2015.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.