ArticleNature cell biology2015
Metabolic exit from naive pluripotency.
Article in Nature cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Hallmarks of totipotent and pluripotent stem cell states.Cell stem cell · 2024Review
- Metabolic Quadrivalency in RSeT Human Embryonic Stem Cells.bioRxiv : the preprint server for biology · 2024Article
- Cross-species single-cell transcriptomic analysis reveals pre-gastrulation developmental differences among pigs, monkeys, and humans.Cell discovery · 2021Article
- Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.Nature communications · 2019Article
- Metabolic Signaling into Chromatin Modifications in the Regulation of Gene Expression.International journal of molecular sciences · 2018Review
- RAS Regulates the Transition from Naive to Primed Pluripotent Stem Cells.Stem cell reports · 2018Article
- Direct comparison of distinct naive pluripotent states in human embryonic stem cells.Nature communications · 2017Article
- Metabolic plasticity complements the unique nature and demands of distinct pluripotency states.Stem cell investigation · 2017Article
- Interspecies chimeric complementation for the generation of functional human tissues and organs in large animal hosts.Transgenic research · 2016Review
- Metabolic remodeling in early development and cardiomyocyte maturation.Seminars in cell & developmental biology · 2016Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spatiotemporally distinct pluripotent states captured in vitro provide an accessible way of modelling early human development. An intricate interplay between the metabolome and histone modifications is now shown to drive the metabolic switch from human naive to primed pluripotency, one of the earliest steps of embryogenesis.
Indexed as
Identifiers
26612574What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.