ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016
Association of Sleep Disordered Breathing with Wake-Up Acute Ischemic Stroke: A Full Polysomnographic Study.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Wake-up stroke and sleep-disordered breathing: a meta-analysis of current studies.Journal of neurology · 2018Pooled it
- Obstructive Sleep Apnea and Stroke: Determining the Mechanisms Behind their Association and Treatment Options.Translational stroke research · 2024Review
- Impact of site, size and severity of ischemic cerebrovascular stroke on sleep in a sample of Egyptian patients a polysomnographic study.BMC neurology · 2023Article
- No Difference in Sleep Desaturations Severity between Patients with Wake-Up and Non-Wake-Up Stroke: A PRESS Study Results.Life (Basel, Switzerland) · 2023Article
- Sleep-Disordered Breathing in Acute Stroke: A Single-Center, Prospective, Longitudinal Study.Journal of clinical medicine · 2023Article
- Rapid eye movement (REM) sleep microarchitecture is altered in patients with wake-up ischemic stroke: A polysomnographic study.Neurobiology of sleep and circadian rhythms · 2021Article
- Wake-up stroke: imaging-based diagnosis and recanalization therapy.Journal of neurology · 2021Review
- High prevalence of obstructive sleep apnea syndrome in Spain's Stroke Belt.The Journal of international medical research · 2021Article
- Wake-up strokes are linked to obstructive sleep apnea and worse early functional outcome.Brain and behavior · 2021Observational
- Wake-up stroke is not associated with obstructive sleep apnea.Sleep medicine · 2021Article
- Stroke during sleep and obstructive sleep apnea: there is a link.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019Observational
- Increased Risk of Ischemic Stroke during Sleep in Apneic Patients.Journal of clinical neurology (Seoul, Korea) · 2018Article
- Wake-up stroke is not associated with sleep-disordered breathing in women.Neurology. Clinical practice · 2018Article
- Sleep-wake disturbance in patients with brain tumors.Neuro-oncology · 2017Review
- Wake-up Call to Identify Obstructive Sleep Apnea in Patients with Ischemic Strokes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016Article
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesSleep disordered breathing (SDB) is a frequent comorbidity in stroke patients. SDB is one of the independent risk factors for ischemic stroke. Conversely, stroke may contribute to SDB onset or aggravate premorbid SDB. Multiple mechanisms underlying SDB might be responsible for the development of stroke. The aim of this study was to compare polysomnographic, clinical, and laboratory characteristics of wake-up (WUS) and non-wake-up acute ischemic strokes (NWUS).
methodsWe prospectively enrolled 88 patients with acute ischemic stroke. Clinical characteristics of the population were recorded on admission, and blood samples were obtained in the fasting condition following morning. SDB was assessed using standard overnight polysomnography in the acute phase of the stroke.
resultsWUS were present in 16 patients (18.2%), and NWUS in 72 patients (81.8%). In WUS compared to NWUS, we observed significantly higher values of apnea-hypopnea index (24.8 vs. 7.6, p = 0.007), desaturation index ([DI] 26.9 vs. 8.8, p = 0.005), arousal index (22.6 vs. 13.1, p = 0.035), diastolic blood pressure (91.6 mm Hg vs. 85.2 mm Hg, p = 0.039), triglyceride levels ([TG] 1.9 mmol/L vs. 1.2 mmol/L, p = 0.049), and significantly lower levels of D-dimer (0.4 μg/L vs. 0.7 μg/L, p = 0.035). DI (CI: 1.003-1.054, p = 0.031) and TG (CI: 1.002-1.877, p = 0.049) were the only independent variables significantly associated with WUS in binary logistic regression model.
conclusionsAlthough the design of our study does not prove the causal relationship between SDB and WUS, higher severity of SDB parameters in WUS supports this hypothesis. COMMENTARY: A commentary on this article appears in this issue on page 467.
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