SynthesisThe British journal of radiology2016
Standard-b-value vs low-b-value DWI for differentiation of benign and malignant vertebral fractures: a meta-analysis.
Synthesis in The British journal of radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Diagnostic Performance of Diffusion-Weighted Imaging for Differentiating Malignant From Benign Intraductal Papillary Mucinous Neoplasms of the Pancreas: A Systematic Review and Meta-Analysis.Frontiers in oncology · 2021Pooled it
- ADC as a useful diagnostic tool for differentiating benign and malignant vertebral bone marrow lesions and compression fractures: a systematic review and meta-analysis.European radiology · 2018Pooled it
- Comments on "Standard-b-value vs low-b-value DWI for differentiation of benign and malignant vertebral fractures: a meta-analysis".The British journal of radiology · 2016Pooled it
- Vertebral fragility fractures mimicking metastases in patients with hormone-sensitive cancers: A clinical highlight.Joint diseases and related surgery · 2026Article
- Current progress and future trends in imaging of musculoskeletal bone tumours.Journal of clinical orthopaedics and trauma · 2021Article
- An update in musculoskeletal tumors: from quantitative imaging to radiomics.La Radiologia medica · 2021Review
- Single shot zonal oblique multislice SE-EPI diffusion-weighted imaging with low to ultra-high b-values for the differentiation of benign and malignant vertebral spinal fractures.European journal of radiology open · 2021Article
- Diffusion-Weighted Imaging in Oncology: An Update.Cancers · 2020Review
- Role of diffusion-weighted magnetic resonance imaging in the evaluation of vertebral bone marrow lesions.Polish journal of radiology · 2020Article
- Accuracy of diffusion-weighted imaging in discriminating atypical vertebral haemangiomas from malignant masses in patients with vertebral lesions: a cross-sectional study.Polish journal of radiology · 2020Article
- Review of the Imaging Features of Benign Osteoporotic and Malignant Vertebral Compression Fractures.AJNR. American journal of neuroradiology · 2018Review
- Dynamic contrast-enhanced and diffusion-weighted MR imaging in the characterisation of small, non-palpable solid testicular tumours.European radiology · 2018Article
- Advances in whole body MRI for musculoskeletal imaging: Diffusion-weighted imaging.Journal of clinical orthopaedics and traumaReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the comparative diagnostic performance of standard-b-value (≥500 mm(2)) vs low-b-value (<500s mm(-2)) diffusion-weighted imaging (DWI) for discriminating malignant from benign vertebral compression fractures.
methods12 studies with a total of 350 malignant and 312 benign vertebral fractures were included.
resultsThe apparent diffusion coefficient (ADC) value of benign vertebral compression fractures was lower than that of malignant vertebral compression fractures (SMD = 1.81, 95% CI 0.98 to 2.64 Z = 4.27, p < 0.05). ADC value difference was more pronounced in the group of low-b-value DWI (SMD = 2.31, 95% CI 1.02 to 3.60 Z = 3.51, p < 0.05) than in the group of standard-b-value DWI (SMD = 1.38, 95% CI 0.18 to 2.59 Z = 2.25, p < 0.05). Ethnicity stratified analysis demonstrated higher ADC values in benign vertebral compression fractures in comparison to malignant tissues in both the Asian and Caucasian subgroups (Asians: SMD = 2.400, 95%CI 1.45 to approximately 3.35, p<0.05; Caucasians: SMD = 0.592, 95 % CI -0.848 to approximately 2.032, p < 0.05). And the ADC value difference was more pronounced in the Asian subgroup.
conclusionADC value appears to be a reliable method to differentiate benign from malignant fractures. Low-b-value DWI was more a valuable parameter than standard-b-value DWI for discriminating malignant from benign vertebral compression fractures. And the diffusion characteristics of the benign vertebral fractures such as osteoporosis, trauma and infection have rarely been investigated separately. ADVANCES IN KNOWLEDGE: The use of low-b-value DWI for differentiation of benign and malignant vertebral fractures is recommended.
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