ArticleSleep2016
EphA4 is Involved in Sleep Regulation but Not in the Electrophysiological Response to Sleep Deprivation.
Article in Sleep, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- Inhibition of Ephrin receptor signaling in the paraventricular nucleus attenuates psoriasis-like dermatitis via synaptic plasticity and immune homeostasis modulation.Journal of neuroinflammation · 2025Article
- The absence of Neuroligin-1 shapes wake/sleep architecture, rhythmic and arrhythmic activities of the electrocorticogram in female mice.Molecular brain · 2025Article
- Revisiting brain gene expression changes and protein modifications tracking homeostatic sleep pressure.Npj biological timing and sleep · 2025Review
- Structural neuroplasticity after sleep loss modifies behavior and requires neurexin and neuroligin.iScience · 2024Article
- Neuroligin-2 shapes individual slow waves during slow-wave sleep and the response to sleep deprivation in mice.Molecular autism · 2024Article
- Hippocampal injections of soluble amyloid-beta oligomers alter electroencephalographic activity during wake and slow-wave sleep in rats.Alzheimer's research & therapy · 2023Article
- Sleep-inducing effect of Rhynchophylline inSleep advances : a journal of the Sleep Research Society · 2023Article
- Concurrent behavioral and electrophysiological longitudinal recordings forFrontiers in aging neuroscience · 2022Article
- Genetic Pathways Associated With Sleep Problems in Children With Autism Spectrum Disorder.Frontiers in psychiatry · 2022Article
- Cellular Effects of Rhynchophylline and Relevance to Sleep Regulation.Clocks & sleep · 2021Review
- Fxr1 regulates sleep and synaptic homeostasis.The EMBO journal · 2020Article
- Scale-Free Dynamics of the Mouse Wakefulness and Sleep Electroencephalogram Quantified Using Wavelet-Leaders.Clocks & sleep · 2019Article
- The effect of Neuroligin-2 absence on sleep architecture and electroencephalographic activity in mice.Molecular brain · 2018Article
- Circadian rhythm and sleep-wake systems share the dynamic extracellular synaptic milieu.Neurobiology of sleep and circadian rhythms · 2018Review
- An LHX1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks.Current biology : CB · 2017Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesOptimal sleep is ensured by the interaction of circadian and homeostatic processes. Although synaptic plasticity seems to contribute to both processes, the specific players involved are not well understood. The EphA4 tyrosine kinase receptor is a cell adhesion protein regulating synaptic plasticity. We investigated the role of EphA4 in sleep regulation using electrocorticography in mice lacking EphA4 and gene expression measurements.
methodsEphA4 knockout (KO) mice, Clock(Δ19/Δ19) mutant mice and littermates, C57BL/6J and CD-1 mice, and Sprague-Dawley rats were studied under a 12 h light: 12 h dark cycle, under undisturbed conditions or 6 h sleep deprivation (SLD), and submitted to a 48 h electrophysiological recording and/or brain sampling at different time of day.
resultsEphA4 KO mice showed less rapid eye movement sleep (REMS), enhanced duration of individual bouts of wakefulness and nonrapid eye movement sleep (NREMS) during the light period, and a blunted daily rhythm of NREMS sigma activity. The NREMS delta activity response to SLD was unchanged in EphA4 KO mice. However, SLD increased EphA4 expression in the thalamic/hypothalamic region in C57BL/6J mice. We further show the presence of E-boxes in the promoter region of EphA4, a lower expression of EphA4 in Clock mutant mice, a rhythmic expression of EphA4 ligands in several brain areas, expression of EphA4 in the suprachiasmatic nuclei of the hypothalamus (SCN), and finally an unchanged number of cells expressing Vip, Grp and Avp in the SCN of EphA4 KO mice.
conclusionsOur results suggest that EphA4 is involved in circadian sleep regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.