ArticleScientific reports2015
In Vivo Voltage-Sensitive Dye Imaging of Subcortical Brain Function.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
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- Real-time monitoring of microdistribution of antibody-photon absorber conjugates during photoimmunotherapy in vivo.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Optical imaging of the rat brain suggests a previously missing link between top-down and bottom-up nervous system function.Neurophotonics · 2017Article
- High-dynamic-range fluorescence laminar optical tomography (HDR-FLOT).Biomedical optics express · 2017Article
- Correlation between volumetric oxygenation responses and electrophysiology identifies deep thalamocortical activity during epileptic seizures.Neurophotonics · 2017Article
- Review of mesoscopic optical tomography for depth-resolved imaging of hemodynamic changes and neural activities.Neurophotonics · 2017Review
- Depth-resolved imaging of colon tumor using optical coherence tomography and fluorescence laminar optical tomography.Biomedical optics express · 2016Article
- Voltage imaging to understand connections and functions of neuronal circuits.Journal of neurophysiology · 2016Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The whisker system of rodents is an excellent model to study peripherally evoked neural activity in the brain. Discrete neural modules represent each whisker in the somatosensory cortex ("barrels"), thalamus ("barreloids"), and brain stem ("barrelettes"). Stimulation of a single whisker evokes neural activity sequentially in its corresponding barrelette, barreloid, and barrel. Conventional optical imaging of functional activation in the brain is limited to surface structures such as the cerebral cortex. To access subcortical structures and image sensory-evoked neural activity, we designed a needle-based optical system using gradient-index (GRIN) rod lens. We performed voltage-sensitive dye imaging (VSDi) with GRIN rod lens to visualize neural activity evoked in the thalamic barreloids by deflection of whiskers in vivo. We stimulated several whiskers together to determine the sensitivity of our approach in differentiating between different barreloid responses. We also carried out stimulation of different whiskers at different times. Finally, we used muscimol in the barrel cortex to silence the corticothalamic inputs while imaging in the thalamus. Our results show that it is possible to obtain functional maps of the sensory periphery in deep brain structures such as the thalamic barreloids. Our approach can be broadly applicable to functional imaging of other core brain structures.
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Registered trials
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