ArticleChinese medical journal2015
Lack of Efficacy of Ulinastatin Therapy During Cardiopulmonary Bypass Surgery.
Article in Chinese medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- The effect of Ulinastatin on postoperative course in cardiopulmonary bypass patients in Asia: a meta-analysis of randomized controlled trials.Journal of cardiothoracic surgery · 2022Pooled it
- Pooled it
- Pooled it
- Ulinastatin treatment for acute respiratory distress syndrome in China: a meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2019Pooled it
- Article
- Inflammatory risk stratification individualizes anti-inflammatory pharmacotherapy for acute type A aortic dissection.Innovation (Cambridge (Mass.)) · 2023Article
- Tranexamic acid after cardiopulmonary bypass does not increase risk of postoperative seizures: a retrospective study.General thoracic and cardiovascular surgery · 2022Article
- Effects of ulinastatin combined with mechanical ventilation on oxygen metabolism, inflammation and stress response and antioxidant capacity of ARDS.Experimental and therapeutic medicine · 2018Article
- Neuroprotective Strategies during Cardiac Surgery with Cardiopulmonary Bypass.International journal of molecular sciences · 2016Review
- Ulinastatin to prevent acute kidney injury after cardiopulmonary bypass surgery: does serum creatinine tell the whole story?Critical care (London, England) · 2016Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt was believed that inflammatory response induced by cardiopulmonary bypass (CPB) was blamed for complications after cardiac surgery. To improve the outcome, many pharmacological interventions have been applied to attenuate inflammatory response during CPB. The objective of this study was to investigate the effect of ulinastatin (urinary trypsin inhibitor [UTI]) on outcome after CPB surgery.
methodsTotally, 208 patients undergoing elective valves replacement between November 2013 and September 2014 were divided into Group U (n = 70) and Group C (n = 138) based on they received UTI or not. Categorical variables were compared between groups using Fisher's exact test, and continuous variables using unpaired Student's t-test or Mann-Whitney U-test. One-way analysis of variance and Dunnett's or Tukey's tests were used to compare values at different time points within the same group. The risk of outcomes was estimated and adjusted by multivariable logistic regression, propensity scoring, and mixed-effect models for all measured variables.
resultsBoth the serious complications in total, including death, acute lung injury, acute respiratory distress syndrome and acute kidney injury, and the other complications, including hemodialysis, infection, re-incubation, and tracheotomy were similar between the two groups (P > 0.05). After adjusted by multivariable logistic regression and the propensity score, UTI still cannot be found any benefit to improve any outcomes after cardiac surgery. Also, no statistical differences with regard to duration of postoperative mechanical ventilation, the length of Intensive Care Unit and hospital stays (P > 0.05).
conclusionUTI did not improve postoperative outcomes in our patients after cardiopulmonary bypass surgery.
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