Evidence map›Paper›PMID 26612280›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2016

Functional Dependence and Mortality in the International Dialysis Outcomes and Practice Patterns Study (DOPPS).

S Vanita Jassal, Angelo Karaboyas, Leah A Comment, Brian A Bieber, Hal Morgenstern, Ananda Sen, Brenda W Gillespie, Patricia De Sequera, Mark R Marshall, Shunichi Fukuhara and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Occupational Priorities of People on Hemodialysis Who Participated in Energy Management Education.Canadian journal of occupational therapy. Revue canadienne d'ergotherapie · 2025
    Trial
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  16. Dialysis in the Elderly: A Practical Guide for the Clinician.International journal of nephrology · 2025
    Review
  17. Article
  18. Article
  19. Article
  20. Article

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 5 countries.

S Vanita JassalDivision of Nephrology, University Health Network, Toronto, Canada.
Angelo KaraboyasArbor Research Collaborative for Health, Ann Arbor, MI.
Leah A CommentArbor Research Collaborative for Health, Ann Arbor, MI; University of Michigan, Ann Arbor, MI.
Brian A BieberArbor Research Collaborative for Health, Ann Arbor, MI.
Hal MorgensternDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI; Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI; Department of Urology, Medical School, University of Michigan, Ann Arbor, MI.
Ananda SenUniversity of Michigan, Ann Arbor, MI.
Brenda W GillespieArbor Research Collaborative for Health, Ann Arbor, MI; University of Michigan, Ann Arbor, MI.
Patricia De SequeraUniversity Hospital Infanta Leonor, Madrid, Spain.
Mark R MarshallFaculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Department of Renal Medicine, Counties Manukau Health, Auckland, New Zealand; Baxter Healthcare (Asia Pacific), Shanghai, People's Republic of China.
Shunichi FukuharaKyoto University, Sakyo-ku, Kyoto, Japan; Center for Innovative Research in Community and Clinical Excellence, Fukushima Medical University, Fukushima, Japan.
Bruce M RobinsonArbor Research Collaborative for Health, Ann Arbor, MI; University of Michigan, Ann Arbor, MI.
Ronald L PisoniArbor Research Collaborative for Health, Ann Arbor, MI.
Francesca TentoriArbor Research Collaborative for Health, Ann Arbor, MI; Vanderbilt University Medical Center, Nashville, TN. Electronic address: francesca.tentori@arborresearch.org.
Arbor Research Collaborative for Health · USUniversity of Michigan–Ann Arbor · USFukushima Medical University · JPHospital Universitario Infanta Leonor · ESUniversity Health Network · CAUniversity of Auckland · NZ

Funding

Quality Dialysis Outcomes & Practice Patterns Study (DOPPS) in hemodialysisK01DK087762 · NIDDK · ARBOR RESEARCH COLLABORATIVE FOR HEALTH · PI TENTORI, FRANCESCA · 2011 to 2015
$744k
NIDDK NIH HHS K01 DK087762NIDDK NIH HHS K01DK087762
6 · The paper itself

Abstract

backgroundPatients receiving long-term dialysis have among the highest mortality and hospitalization rates. In the nonrenal literature, functional dependence is recognized as a contributor to subsequent disability, recurrent hospitalization, and increased mortality. A higher burden of functional dependence with progressive worsening of kidney function has been observed in several studies, suggesting that functional dependence may contribute to both morbidity and mortality in dialysis patients. STUDY

designProspective cohort study. SETTING &

participants7,226 hemodialysis patients from 12 countries in the DOPPS (Dialysis Outcomes and Practice Patterns Study) phase 4 (2009-2011) with self-reported data for functional status. PREDICTOR: Patients' ability to perform 13 basic and instrumental activities of daily living was summarized to create an overall functional status score (range, 1.25 [most dependent] to 13 [functionally independent]). OUTCOME: Cox regression was used to estimate the association between functional status and all-cause mortality, adjusting for several demographic and clinical risk factors for mortality. Median follow-up was 17.2 months.

resultsThe proportion of patients who could perform each activity of daily living task without assistance ranged from 97% (eating) to 47% (doing housework). 36% of patients could perform all 13 tasks without assistance (functional status = 13), and 14% of patients had high functional dependence (functional status < 8). Functionally independent patients were younger and had many indicators of better health status, including higher quality of life. Compared with functionally independent patients, the adjusted HR for mortality was 2.37 (95% CI, 1.92-2.94) for patients with functional status < 8. LIMITATIONS: Possible nonresponse bias and residual confounding.

conclusionsWe found a high burden of functional dependence across all age groups and across all DOPPS countries. When adjusting for several known mortality risk factors, including age, access type, cachexia, and multimorbidity, functional dependence was a strong consistent predictor of mortality.

Indexed as

Activities of Daily LivingInternationalityAgedAged, 80 and overCohort StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedMortalityProspective StudiesRenal DialysisTreatment Outcomeactivity of daily living (ADL)Chronic kidney disease (CKD)dialysisDialysis Outcomes and Practice Patterns Study (DOPPS)end-stage renal disease (ESRD)functional dependencefunctional statushospitalizationindependencemorbiditymortalityphysical activityquality of life (QoL)

Identifiers

PMID26612280
PMCPMC5530761
OpenAlexW2175003259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.