Evidence map›Paper›PMID 26612240›Full record

ReviewBest practice & research. Clinical rheumatology2015

Carpal tunnel syndrome and work.

Lisa Newington, E Clare Harris, Karen Walker-Bone

6 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Best practice & research. Clinical rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 72 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03532373 nacompletednot on this mapstarted 2021, after this paper: background citation

Testing of a Tool to Elicit Patient Preferences for CTS

TypeinterventionalSponsorStanford UniversityRan2021 to 2023Enrolled49ConditionsCarpal Tunnel, Carpal Tunnel Syndrome, Carpal Tunnel Syndrome Left, Carpal Tunnel Syndrome RightArmsPreference Elicitation tool
NCT03970408 completednot on this mapstarted 2019, after this paper: background citation

Effect of Neck Movements on Median Nerve Longitudinal Excursion During Neurodynamic Mobilization in Patients With Carpal Tunnel Syndrome

TypeobservationalSponsorAliaa Rehan YoussefRan2019 to 2020Enrolled18ConditionsCTSArmsMNT1
NCT05466162 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effects of Soft Tissue Massage Along With Mobilization Technique on Intensity of Symptoms and Functional Status of Carpal Tunnel Syndrome - A Randomized Controlled Trial

TypeinterventionalSponsorDow University of Health SciencesRan2021 to 2022Enrolled60ConditionsCarpal Tunnel SyndromeArmsSoft tissue mobilization, Joint and nerve mobilization
NCT06239259 recruitingnot on this mapstarted 2023, after this paper: background citation

Validity and Reliability of Thai Version of Kamath and Stothard Clinical Questionnaire for Diagnosis of Carpal Tunnel Syndrome

TypeobservationalSponsorSiriraj HospitalRan2023 to 2026Enrolled80ConditionsCarpal Tunnel SyndromeArmsQuestionare As described in Secondary Outcomes
NCT06399380 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Immediate Effect of Manual Mobilization of the Carpal Bones on the Neural Conduction of the Median Nerve in Patients With Carpal Tunnel Syndrome: Randomized Clinical Trial

TypeinterventionalSponsorUniversidad de ZaragozaRan2024 to 2024Enrolled30ConditionsCarpal Tunnel SyndromeArmsManual mobilization of the carpal bones., Placebo
NCT06952647 completednot on this mapstarted 2025, after this paper: background citation

Hematological and Metabolic Markers in Carpal Tunnel Syndrome

TypeobservationalSponsorAnkara Training and Research HospitalRan2025 to 2026Enrolled197ConditionsCarpal Tunnel Syndrome (CTS), Biomarkers / Blood
3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 2 syntheses or guidelines pooled it, 196 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The Median Nerve Displays Adaptive Characteristics When Exposed to Repeated Pinch Grip Efforts of Varying Rates of Force Development: An Ultrasonic Investigation.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Article
  17. RETURN TO WORK AFTER CARPAL TUNNEL RELEASE SURGERY.Acta ortopedica brasileira · 2025
    Article
  18. Observational
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Lisa NewingtonArthritis Research UK/MRC Centre for Musculoskeletal Health and Work, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; Hand Therapy, Chelsea and Westminster Hospital NHS Foundation Trust, 369 Fulham Road, London SW10 9NH, UK.
E Clare HarrisArthritis Research UK/MRC Centre for Musculoskeletal Health and Work, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.
Karen Walker-BoneArthritis Research UK/MRC Centre for Musculoskeletal Health and Work, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK; MRC Lifecourse Epidemiology Unit, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK. Electronic address: kwb@mrc.soton.ac.uk.
Southampton General Hospital · GBMRC Lifecourse Epidemiology Unit · GB

Funding

Arthritis Research UK 20665Medical Research Council MC_PC_15015Medical Research Council MC_U147585823Medical Research Council MC_UP_A620_1018Medical Research Council MC_UU_12011/5
6 · The paper itself

Abstract

Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment syndrome, and it frequently presents in working-aged adults. Its mild form causes 'nuisance' symptoms including dysaesthesia and nocturnal waking. At its most severe, CTS can significantly impair motor function and weaken pinch grip. This review discusses the anatomy of the carpal tunnel and the clinical presentation of the syndrome as well as the classification and diagnosis of the condition. CTS has a profile of well-established risk factors including individual factors and predisposing co-morbidities, which are briefly discussed. There is a growing body of evidence for an association between CTS and various occupational factors, which is also explored. Management of CTS, conservative and surgical, is described. Finally, the issue of safe return to work post carpal tunnel release surgery and the lack of evidence-based guidelines are discussed.

Indexed as

Carpal Tunnel SyndromeHumansOccupational DiseasesOccupational ExposureRisk FactorsWork Capacity EvaluationCarpal tunnel syndromeOccupationRepetitionReturn to workVibration

Identifiers

PMID26612240
PMCPMC4759938
OpenAlexW415097942

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.