ArticleEuropean archives of psychiatry and clinical neuroscience2016
Cognitive deficits in bipolar disorder: from acute episode to remission.
Article in European archives of psychiatry and clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Cognitive impairment in bipolar disorder in comparison to mild cognitive impairment and dementia: a systematic review.Trends in psychiatry and psychotherapy · 2023Pooled it
- Effects of Deep Transcranial Magnetic Stimulation on Cognitive Function in Bipolar Depression: A Randomized Controlled Trial Using the MATRICS Consensus Cognitive Battery.Alpha psychiatry · 2026Article
- High perceived energy: exploring distinct patterns of energetic and cognitive functioning in older adults.Frontiers in psychiatry · 2026Article
- Investigating topological alterations in procedural memory network across neuropsychiatric disorders using rs-fMRI and graph theory.BMC neuroscience · 2025Article
- Investigating resting-state functional connectivity changes within procedural memory network across neuropsychiatric disorders using fMRI.BMC medical imaging · 2025Article
- Cognitive functions in euthymic bipolar I and II patients: a cross sectional study.Frontiers in psychiatry · 2025Article
- A systematic review of the biomarkers associated with cognition and mood state in bipolar disorder.International journal of bipolar disorders · 2024Article
- Neural Responses to a Working Memory Task in Acute Depressed and Remitted Phases in Bipolar Patients.Brain sciences · 2023Article
- Functional connectivity alterations of the somatomotor network in euthymic bipolar disorder.Neuroscience applied · 2023Article
- Processing speed - A potential candidate cognitive endophenotype for bipolar disorder.Journal of affective disorders reports · 2023Article
- Better than expected: the gap between self-reported and objective measures of cognitive performance in remitted bipolar disorder.Frontiers in psychiatry · 2023Article
- MICEmi: A method to identify cognitive endophenotypes of mental illnesses.European psychiatry : the journal of the Association of European Psychiatrists · 2022Review
- Neuropsychological exponents for the driving ability in remitted bipolar patients.International journal of bipolar disorders · 2022Article
- Cognitive Processes and Legal Capacity in Patients With Bipolar Disorder: A Brief Research Report.Frontiers in psychology · 2022Article
- The Heterogeneity of Longitudinal Cognitive Decline in Euthymic Bipolar I Disorder With Clinical Characteristics and Functional Outcomes.Frontiers in psychiatry · 2021Article
- Resting-State Network Patterns Underlying Cognitive Function in Bipolar Disorder: A Graph Theoretical Analysis.Brain connectivity · 2020Article
- Association of Lipid Peroxidation and Brain-Derived Neurotrophic Factor with Executive Function in Adolescent Bipolar Disorder.Psychopharmacology · 2017Article
- No differences in visual theory of mind abilities between euthymic bipolar patients and healthy controls.International journal of bipolar disorders · 2016Article
- Neurocognitive functioning in individuals with bipolar disorder and their healthy siblings: A preliminary study.Journal of affective disorders · 2016Article
- Roles of C-reactive protein polymorphisms and life event changes on cognitive function in bipolar patients receiving valproate.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Considerable evidence demonstrates that neuropsychological deficits are prevalent in bipolar disorder during both acute episodes and euthymia. However, it is less clear whether these cognitive disturbances are state- or trait-related. We here present the first longitudinal study employing a within-subject pre- and post-testing examining acutely admitted bipolar patients (BP) in depression or mania and during euthymia, aiming to identify cognitive performance from acute illness to remission. Cognitive performance was measured during acute episodes and repeated after at least 3 months of remission. To do so, 55 BP (35 depressed, 20 hypo-/manic) and 55 healthy controls (HC) were tested with a neuropsychological test battery (attention, working memory, verbal memory, executive functioning). The results showed global impairments in acutely ill BP compared to HC: depressed patients showed a characteristic psychomotor slowing, while manic patients had severe deficits in executive functioning. Twenty-nine remitted BP could be measured in the follow-up (dropout rate 48 %), whose cognitive functions partially recovered, whereas working memory and verbal memory were still impaired. However, we found that subthreshold depressive symptoms and persisting sleep disturbances in euthymic BP were associated with reduced speed, deficits in attention and verbal memory, while working memory was correlated with psychotic symptoms (lifetime). This result indicates working memory as trait related for a subgroup of BP with psychotic symptoms. In contrast, attention and verbal memory are negatively influenced by state factors like residual symptoms, which should be more considered as possible confounders in the search of cognitive endophenotypes in remitted BP.
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